About: Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism

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About: Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism
Creator	Nan, Yuchen Zhang, Yan-Jin Wu, Chunyan Bayry, Jagadeesh Xing, Junji Moseley, Gregory
Source	Medline; PMC
abstract	Interferons (IFNs), which were discovered a half century ago, are a group of secreted proteins that play key roles in innate immunity against viral infection. The major signaling pathway activated by IFNs is the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, which leads to the expression of IFN-stimulated genes (ISGs), including many antiviral effectors. Viruses have evolved various strategies with which to antagonize the JAK/STAT pathway to influence viral virulence and pathogenesis. In recent years, notable progress has been made to better understand the JAK/STAT pathway activated by IFNs and antagonized by viruses. In this review, recent progress in research of the JAK/STAT pathway activated by type I IFNs, non-canonical STAT activation, viral antagonism of the JAK/STAT pathway, removing of the JAK/STAT antagonist from viral genome for attenuation, and the potential pathogenesis roles of tyrosine phosphorylation-independent non-canonical STATs activation during virus infection are discussed in detail. We expect that this review will provide new insight into the understanding the complexity of the interplay between JAK/STAT signaling and viral antagonism.
has issue date	2017-12-11(xsd:dateTime)
bibo:doi	10.3389/fimmu.2017.01758
bibo:pmid	29312301
has license	cc-by
sha1sum (hex)	56948f3e281e7271f952181ed0c3bd83d1d70f8e
schema:url	https://doi.org/10.3389/fimmu.2017.01758
resource representing a document's title	Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism
has PubMed Central identifier	PMC5732261
has PubMed identifier	29312301
schema:publication	Front Immunol
resource representing a document's body	covid:56948f3e281e7271f952181ed0c3bd83d1d70f8e#body_text
is schema:about of	named entity 'ANTAGONISM' named entity 'VIRAL' named entity 'TYPE I INTERFERONS' named entity 'SIGNALING' named entity 'ACTIVATED' named entity 'SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION' named entity 'JANUS KINASE' named entity 'STAT3' named entity 'receptor' named entity 'mutation' named entity 'STATs' named entity 'NF-κB' named entity 'STAT' named entity 'IFN' named entity 'antiviral' named entity 'phenotype' named entity 'pathogenesis' named entity 'decoy receptor' named entity 'non-structural protein' named entity 'STAT1' named entity 'phosphorylated' named entity 'measles virus' named entity 'transcription activator' named entity 'homeostatic' named entity 'transformed cells' named entity 'H1N1 influenza A virus' named entity 'SOCS' named entity 'serine' named entity 'STATs' named entity 'SOCS1' named entity 'log reduction' named entity 'wild-type' named entity 'phenotype' named entity 'prognosis' named entity 'antiviral' named entity 'varicella-zoster virus' named entity 'phosphorylated' named entity 'infection' named entity 'modified live' named entity 'STATs' named entity 'viral protein' named entity 'cytokine' named entity 'STATs' named entity 'lung' named entity 'proinflammatory cytokines' named entity 'IL-26' named entity 'miR-26a' named entity 'STAT1' named entity 'virulence' named entity 'phosphorylation' named entity 'cytokine' named entity 'cross talk' named entity 'STAT5' named entity 'phosphorylation sites' named entity 'VZV' named entity 'phosphorylation' named entity 'STAT3' named entity 'type I IFN' named entity 'JAK/STAT' named entity 'SOCS3' named entity 'paramyxoviruses' named entity 'JAK/STAT' named entity 'JAK/STAT pathway' named entity 'Smallpox' named entity 'downregulates' named entity 'homodimer' named entity 'phosphorylation' named entity 'JAK/STAT' named entity 'STAT3' named entity 'IL-21' named entity 'phosphorylation' named entity 'STAT1' named entity 'serine' named entity 'variola virus' named entity 'homology' named entity 'STAT'

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