About: Evaluation and Comparison of the Pathogenicity and Host Immune Responses Induced by a G2b Taiwan Porcine Epidemic Diarrhea Virus (Strain Pintung 52) and Its Highly Cell-Culture Passaged Strain in Conventional 5-Week-Old Pigs

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About: Evaluation and Comparison of the Pathogenicity and Host Immune Responses Induced by a G2b Taiwan Porcine Epidemic Diarrhea Virus (Strain Pintung 52) and Its Highly Cell-Culture Passaged Strain in Conventional 5-Week-Old Pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation and Comparison of the Pathogenicity and Host Immune Responses Induced by a G2b Taiwan Porcine Epidemic Diarrhea Virus (Strain Pintung 52) and Its Highly Cell-Culture Passaged Strain in Conventional 5-Week-Old Pigs
Creator	Chang, Hui-Wen Jeng, Chian-Ren Cheng, Ivan-Chen Chang, Chia-Yu Chang, Yen-Chen Chiou, Hue-Ying Peng, Ju-Yi Tsai, Pei-Shiue Dixon, Linda Kao, Chi-Fei Graham, Simon Pang, Victor
Source	Medline; PMC
abstract	A genogroup 2b (G2b) porcine epidemic diarrhea virus (PEDV) Taiwan Pintung 52 (PEDVPT) strain was isolated in 2014. The pathogenicity and host antibody responses elicited by low-passage (passage 5; PEDVPT-P5) and high-passage (passage 96; PEDVPT-P96) PEDVPT strains were compared in post-weaning PEDV-seronegative pigs by oral inoculation. PEDVPT-P5-inoculation induced typical diarrhea during 1–9 days post inoculation with fecal viral shedding persisting for 26 days. Compared to PEDVPT-P5, PEDVPT-P96 inoculation induced none-to-mild diarrhea and lower, delayed fecal viral shedding. Although PEDVPT-P96 elicited slightly lower neutralizing antibodies and PEDV-specific immunoglobulin G (IgG) and immunoglobulin A (IgA) titers, a reduction in pathogenicity and viral shedding of the subsequent challenge with PEDVPT-P5 were noted in both PEDVPT-P5- and PEDVPT-P96-inoculated pigs. Alignment and comparison of full-length sequences of PEDVPT-P5 and PEDVPT-P96 revealed 23 nucleotide changes and resultant 19 amino acid substitutions in non-structure proteins 2, 3, 4, 9, 14, 15, spike, open reading frame 3 (ORF3), and membrane proteins with no detectable deletion or insertion. The present study confirmed the pathogenicity of the PEDVPT isolate in conventional post-weaning pigs. Moreover, data regarding viral attenuation and potency of induced antibodies against PEDVPT-P5 identified PEDVPT-P96 as a potential live-attenuated vaccine candidate.
has issue date	2017-05-19(xsd:dateTime)
bibo:doi	10.3390/v9050121
bibo:pmid	28534849
has license	cc-by
sha1sum (hex)	569f5c13c3109817f6ce0882e4129f31e83cfd29
schema:url	https://doi.org/10.3390/v9050121
resource representing a document's title	Evaluation and Comparison of the Pathogenicity and Host Immune Responses Induced by a G2b Taiwan Porcine Epidemic Diarrhea Virus (Strain Pintung 52) and Its Highly Cell-Culture Passaged Strain in Conventional 5-Week-Old Pigs
has PubMed Central identifier	PMC5454433
has PubMed identifier	28534849
schema:publication	Viruses
resource representing a document's body	covid:569f5c13c3109817f6ce0882e4129f31e83cfd29#body_text
is schema:about of	named entity 'COMPARISON' covid:arg/569f5c13c3109817f6ce0882e4129f31e83cfd29 named entity 'PASSAGE' named entity 'STRAIN' named entity 'POST' named entity 'POTENCY' named entity 'INDUCED' named entity 'SPIKE' named entity 'CONVENTIONAL' named entity 'ANTIBODIES' named entity 'ELICITED BY' named entity 'DAYS' named entity 'NUCLEOTIDE' named entity 'STUDY' named entity 'PROTEINS' named entity 'POTENTIAL' named entity 'FECAL' named entity 'COMPARISON' named entity 'NOTED' named entity 'LIVE' named entity 'ISOLATE' named entity 'DETECTABLE' named entity 'MILD' named entity 'SPECIFIC' named entity 'TAIWAN' named entity 'HOST' named entity 'MEMBRANE PROTEINS' named entity 'DIARRHEA' named entity 'OPEN READING FRAME' named entity 'DATA' named entity 'REVEALED' named entity 'STRAINS' named entity 'DELETION' named entity 'DELAYED' named entity 'VACCINE CANDIDATE' named entity 'SUBSEQUENT' named entity 'HOST' named entity 'REDUCTION' named entity 'P96' named entity 'LENGTH' named entity 'LOWER' named entity 'CHALLENGE' named entity 'PRESENT' named entity 'PATHOGENICITY' named entity 'VIRAL' named entity 'PATHOGENICITY' named entity 'INDUCED' named entity 'CULTURE' named entity 'HIGHLY' named entity 'NON-' named entity 'INOCULATION' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'CONVENTIONAL' named entity 'OLD' named entity 'ITS' named entity 'CELL' named entity 'PIGS' named entity 'WEEK' named entity 'STRAIN' named entity 'TAIWAN' named entity 'INSERTION' named entity 'CONFIRMED' named entity 'ATTENUATION' named entity 'HIGH' named entity 'ATTENUATED VACCINE' named entity 'SEQUENCES' named entity 'ALIGNMENT' named entity 'CHANGES' named entity 'VIRAL SHEDDING' named entity 'EVALUATION'

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