About: Immune recovery following bronchiolitis is linked to a drop in cytokine and LTC4 levels

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About: Immune recovery following bronchiolitis is linked to a drop in cytokine and LTC4 levels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immune recovery following bronchiolitis is linked to a drop in cytokine and LTC4 levels
Creator	Casas, Inmaculada Calvo, Cristina Luz García-García, María Del Pozo, Victoria Manuel, José Sastre, Beatriz Cañas, José Mora, Inés
source	Medline; PMC
abstract	BACKGROUND: Bronchiolitis is the main cause of hospitalization of children younger than 1 year; however, the immune mechanism of bronchiolitis is not completely understood. The aim of this study was to analyze the recovery of immune response after a bronchiolitis episode. METHODS: Forty-nine infants hospitalized with bronchiolitis diagnosis were enrolled. Nasopharyngeal aspirates (NPAs) were processed. Twenty-seven pro-inflammatory biomarkers linked to innate immunity, inflammation, and epithelial damage, as well as nitrites and lipid mediators, were evaluated in the NPA supernatant by ELISA (enzyme-linked immunosorbent assay) and Luminex. Also, 11 genes were analyzed in NPA cells by quantitative PCR. RESULTS: A widespread statistically significant decline of multiple pro-inflammatory parameters and cytokines were detected in the recovery period after respiratory infection: interferon-α2 (IFNα2), IFNγ, interleukin-10 (IL-10), IL-1β, IL-8, IFN-γ-inducible protein-10, vascular endothelial growth factor, monocyte chemoattractant protein-1, macrophage inflammatory protein-1α (MIP-1α), and MIP-1β. Supporting these results, a decreased nuclear factor-κB gene expression was observed (P = 0.0116). A significant diminution of cysteinyl leukotriene C4 (LTC4) soluble levels (P = 0.0319) and cyclooxygenase-2 (COX-2) gene expression were observed in the recovery sample. In children classified by post-bronchiolitis wheezing, LTC4 remains elevated in the NPA supernatant. CONCLUSIONS: After bronchiolitis, cytokines and biomarkers linked to innate immune response in NPA decrease significantly in the recovery period accompanied by a drop in LTC4 levels; however, this reduction was lower in infants with post-bronchiolitis wheezing.
has issue date	2019-10-10(xsd:dateTime)
bibo:doi	10.1038/s41390-019-0606-2
bibo:pmid	31600771
has license	no-cc
sha1sum (hex)	56a6eea69f7aad91a41af372aa9021d6a72a8a60
schema:url	https://doi.org/10.1038/s41390-019-0606-2
resource representing a document's title	Immune recovery following bronchiolitis is linked to a drop in cytokine and LTC4 levels
has PubMed Central identifier	PMC7086521
has PubMed identifier	31600771
schema:publication	Pediatr Res
resource representing a document's body	covid:56a6eea69f7aad91a41af372aa9021d6a72a8a60#body_text
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