About: Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU) superfamily of deubiquitinases (DUBs). The publication of the latest of these reports in quick succession prevented proper recognition and discussion of the shared features of these viral enzymes. Here we provide a brief structural and functional comparison of these virus-encoded OTU DUBs. Interestingly, although their shared structural features and substrate specificity tentatively place them within the same protease superfamily, they also show interesting differences that trigger speculation as to their origins.   Goto Sponge  NotDistinct  Permalink

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  • Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU) superfamily of deubiquitinases (DUBs). The publication of the latest of these reports in quick succession prevented proper recognition and discussion of the shared features of these viral enzymes. Here we provide a brief structural and functional comparison of these virus-encoded OTU DUBs. Interestingly, although their shared structural features and substrate specificity tentatively place them within the same protease superfamily, they also show interesting differences that trigger speculation as to their origins.
Subject
  • Enzymes
  • Open access journals
  • Creative Commons Attribution-licensed journals
  • English-language journals
  • Microbiology journals
  • Monthly journals
  • PLoS academic journals
  • Protein domains
  • Books about economic inequality
  • Egalitarianism
  • Bachelor's degrees
  • Liberal arts education
  • Publications established in 2005
  • 2009 non-fiction books
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