About: Possible role of vitamin D in Covid-19 infection in pediatric population

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About: Possible role of vitamin D in Covid-19 infection in pediatric population Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Possible role of vitamin D in Covid-19 infection in pediatric population
Creator	Rossi, · Cappa, · D'argenio, · Fintini, · Panfili, F Roversi, ·
topic	covid:571231c1b44dfeeed6fbdfbaf9235b6c3f5400a3#this
Source	Medline; PMC
abstract	PURPOSE: Covid-19 is a pandemic of unprecedented proportion, whose understanding and management is still under way. In the emergency setting new or available therapies to contrast the spread of COVID-19 are urgently needed. Elderly males, especially those affected by previous diseases or with comorbidities, are more prone to develop interstitial pneumonia that can deteriorate evolving to ARDS (acute respiratory distress syndrome) that require hospitalization in Intensive Care Units (ICUs). Even children and young patients are not spared by SARS-CoV 2 infection, yet they seem to develop a milder form of disease. In this setting the immunomodulatory role of Vitamin D, should be further investigated. Methods: We reviewed the literature about the immunomodulatory role of Vitamin D collecting data from the databases Medline and Embase. RESULTS: Vitamin D proved to interact both with the innate immune system, by activating Toll-like receptors (TLRs) or increasing the levels of cathelicidins and β-defensins, and adaptive immune system, by reducing immunoglobulin secretion by plasma cells and pro-inflammatory cytokines production, thus modulating T cells function. Promising results have been extensively described as regards the supplementation of vitamin D in respiratory tract infections, autoimmune diseases and even pulmonary fibrosis. CONCLUSIONS: In this review, we suggest that vitamin D supplementation might play a role in the prevention and/or treatment to SARS-CoV-2 infection disease, by modulating the immune response to the virus both in the adult and pediatric population.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1007/s40618-020-01327-0
bibo:pmid	32557271
has license	no-cc
sha1sum (hex)	571231c1b44dfeeed6fbdfbaf9235b6c3f5400a3
schema:url	https://doi.org/10.1007/s40618-020-01327-0
resource representing a document's title	Possible role of vitamin D in Covid-19 infection in pediatric population
has PubMed Central identifier	PMC7299247
has PubMed identifier	32557271
schema:publication	J Endocrinol Invest
resource representing a document's body	covid:571231c1b44dfeeed6fbdfbaf9235b6c3f5400a3#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/571231c1b44dfeeed6fbdfbaf9235b6c3f5400a3
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