About: Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?
Creator	Andersen, Julie Buck, Hudson Chamoli, Manish Chinta, Shankar Rane, Anand Viel, Tania
Source	Medline; PMC
abstract	Cell senescence is a process that causes growth arrest and the release of a senescence associated secretory phenotype (SASP), characterized by secretion of chemokines, cytokines, cell growth factors and metalloproteases, leading to a tissue condition that may precipitate cancers and neurodegenerative processes. With the recent pandemic of coronavirus, senolytic drugs are being considered as possible therapeutic tools to reduce the virulence of SARS-CoV-2. In the last few years, our research group showed that lithium carbonate at microdose levels was able to stabilize memory and change neuropathological characteristics of Alzheimer’s disease (AD). In the present work, we present evidence that low-dose lithium can reduce the SASP of human iPSCs-derived astrocytes following acute treatment, suggesting that microdose lithium could protect cells from senescence and development of aging-related conditions. With the present findings, a perspective of the potential use of low-dose lithium in old patients from the “high risk group” for COVID-19 (with hypertension, diabetes and chronic obstructive pulmonary disease) is presented.
has issue date	2020-06-13(xsd:dateTime)
bibo:doi	10.18632/aging.103449
bibo:pmid	32534451
has license	cc-by
sha1sum (hex)	5720beab2f35a2cd51bb0e486d502a8de7166e74
schema:url	https://doi.org/10.18632/aging.103449
resource representing a document's title	Microdose lithium reduces cellular senescence in human astrocytes - a potential pharmacotherapy for COVID-19?
has PubMed Central identifier	PMC7346079
has PubMed identifier	32534451
schema:publication	Aging (Albany NY)
resource representing a document's body	covid:5720beab2f35a2cd51bb0e486d502a8de7166e74#body_text
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