About: Modulation of lethal and persistent rat parvovirus infection by antibody

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Modulation of lethal and persistent rat parvovirus infection by antibody
Creator	Gaertner, Diane Smith, Abigail Jacoby, R Paturzo, F Johnson, Elizabeth Brandsma, Janet
source	PMC
abstract	Two day-old athymic (rnu/rnu) and euthymic (rnu/+) rat pups nursing immune or non-immune dams were inoculated oronasally with the Yale strain of rat virus (RV-Y). All athymic and euthymic pups (57/57) from immune dams remained clinically normal, whereas 51 of 66 athymic and euthymic pups from non-immune dams died within 30 days. Infectious RV was detected by explant culture in 12 of 15 surviving pups of both genotypes from non-immune dams 30 days after inoculation, but in none of the 57 surviving pups from immune dams. RV-Y DNA was detected by Southern blotting in kidneys of surviving athymic pups from non-immune dams but was not detected in pups from immune dams. Euthymic pups from immune dams appeared not to produce endogenous antibody to RV after virus challenge, whereas euthymic pups from non-immune dams produced high-titered RV immune serum. Pups of both genotypes given immune serum prior to or with RV were fully protected from disease and persistent infection, whereas pups given immune serum 24 hours after RV were partially protected. These studies show that RV antibody offers significant protection against lethal and persistent RV infection.
has issue date	1991-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01311299
bibo:pmid	1646590
has license	no-cc
sha1sum (hex)	573661a95f083c52e0d73b1def7bfe6a51fbdb73
schema:url	https://doi.org/10.1007/bf01311299
resource representing a document's title	Modulation of lethal and persistent rat parvovirus infection by antibody
has PubMed Central identifier	PMC7086996
has PubMed identifier	1646590
schema:publication	Arch Virol
resource representing a document's body	covid:573661a95f083c52e0d73b1def7bfe6a51fbdb73#body_text
is schema:about of	named entity 'detected' named entity 'remained' named entity 'pups' named entity 'parvovirus' named entity 'PERSISTENT INFECTION' named entity 'INFECTION' named entity 'STRAIN' named entity 'inoculation' named entity 'dams' named entity 'endogenous' named entity 'pups' named entity 'pups' named entity 'pups' named entity 'kidneys' named entity 'virus' named entity 'explant culture' named entity 'immune' named entity 'athymic' named entity 'athymic' named entity 'euthymic' named entity 'kidneys' named entity 'immune serum' named entity 'endogenous' named entity 'virus' named entity 'explant culture' named entity 'infection' named entity 'euthymic' named entity 'antibody' named entity 'antibody' named entity 'rat' named entity 'infection' named entity 'euthymic' named entity 'heterozygous' named entity 'virus' named entity 'antibody response' named entity 'antibody' named entity 'spleens' named entity 'euthymic' named entity 'passive immunity' named entity 'immunodeficient' named entity 'Kidney' named entity 'immune serum' named entity 'rodent' named entity 'infection' named entity 'hybridized' named entity 'virus' named entity 'inoculation' named entity 'antibody' named entity 'Heterozygous' named entity 'Antibody' named entity 'seronegative' named entity 'carbon dioxide gas' named entity 'Antibody' named entity 'antibody' named entity 'infection' named entity 'rat' named entity 'spleens' named entity 'inoculation' named entity 'immune serum' named entity 'antibodies' named entity 'spleens' named entity 'humoral immune response' named entity 'spleens' named entity 'kidneys' named entity 'Athymic' named entity 'infection' named entity 'Tissues' named entity 'anesthetized' named entity 'infection' named entity 'Clinical signs' named entity 'spleen' named entity 'Rat' named entity 'infection' named entity 'acute infection' named entity 'endogenous' named entity 'euthymic'

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