About: Pentraxin 3: An Immuno-Regulator in the Lungs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pentraxin 3: An Immuno-Regulator in the Lungs
Creator	Garlanda, Cecilia Balhara, Jyoti Zhang, Jingbo Koussih, Latifa Gounni, Abdelilah Humanitas, Istituto Knight, Darryl
Source	Medline; PMC
abstract	Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that is a humoral component of the innate immune system. It interacts with pathogenic moieties, infected and dying host cells and facilitates their removal through activation of appropriate innate and adaptive mechanisms. PTX3 is secreted by a diverse variety of cells, ranging from immune cells to structural cells, in response to Toll like receptor (TLR) engagement, inflammatory stimuli, and physical and chemical stress. Further, PTX3 plays an essential role in female fertility as it facilitates the organization of extracellular matrix in the cumulus oophorus. Such activity is also implicated in post-inflammation tissue repair. PTX3 is a multifunctional protein and plays a non-redundant role in providing immunity against potential immunological dangers. Thus, we assessed its role in lung immunity, as lungs are at a constant risk of infections and tissue damage that is attributable to perpetual exposure to foreign agents.
has issue date	2013-05-31(xsd:dateTime)
bibo:doi	10.3389/fimmu.2013.00127
bibo:pmid	23755050
has license	cc-by
sha1sum (hex)	574efe7771ff8495c4ace678a489b0a0869b0834
schema:url	https://doi.org/10.3389/fimmu.2013.00127
resource representing a document's title	Pentraxin 3: An Immuno-Regulator in the Lungs
has PubMed Central identifier	PMC3668324
has PubMed identifier	23755050
schema:publication	Front Immunol
resource representing a document's body	covid:574efe7771ff8495c4ace678a489b0a0869b0834#body_text
is schema:about of	named entity 'cumulus oophorus' named entity 'dangers' named entity 'female' named entity 'ATTRIBUTABLE' named entity 'INNATE IMMUNE SYSTEM' named entity 'NON-' named entity 'CHEMICAL' named entity 'FOREIGN' named entity 'STRUCTURAL' named entity 'EXPOSURE TO' named entity 'ACTIVATION' named entity 'PLAYS' named entity 'ENGAGEMENT' named entity 'STIMULI' named entity 'ASSESSED' named entity 'PROVIDING' named entity 'TOLL LIKE RECEPTOR' named entity 'VARIETY' named entity 'POTENTIAL' named entity 'MECHANISMS' named entity 'DIVERSE' named entity 'EXTRACELLULAR MATRIX' named entity 'LUNG' named entity 'PROTEIN ' named entity 'PATTERN RECOGNITION RECEPTOR' named entity 'APPROPRIATE' named entity 'INFLAMMATION' named entity 'PENTRAXIN 3' named entity 'INFECTED' named entity 'PATHOGENIC' named entity 'COMPONENT' named entity 'IMMUNOLOGICAL' named entity 'ROLE' named entity 'ORGANIZATION' named entity 'ADAPTIVE' named entity 'PHYSICAL' named entity 'IMMUNITY' named entity 'DYING' named entity 'RESPONSE TO' named entity 'CELLS' named entity 'POST' named entity 'CONSTANT' named entity 'HOST CELLS' named entity 'STRESS' named entity 'REDUNDANT' named entity 'THEIR' named entity 'INFECTIONS' named entity 'TISSUE REPAIR' named entity 'FEMALE FERTILITY' named entity 'REMOVAL' named entity 'CUMULUS OOPHORUS' named entity 'SOLUBLE' named entity 'TISSUE DAMAGE' named entity 'RISK OF' named entity 'IMMUNE CELLS' named entity 'ESSENTIAL' named entity 'REGULATOR' named entity 'PENTRAXIN 3' named entity 'THE LUNGS' named entity 'ITS' named entity 'PTX3' named entity 'ACTIVITY' named entity 'INFLAMMATORY' named entity 'SECRETED' named entity 'IS A' named entity 'LUNGS' named entity 'adaptive' named entity 'lungs' named entity 'activation' named entity 'immunological' named entity 'tissue' named entity 'chemical' named entity 'pathogenic' named entity 'humoral' named entity 'innate immune'

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