About: LC16m8: An attenuated smallpox vaccine

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	LC16m8: An attenuated smallpox vaccine
Creator	Gurwith, Marc Cameron, Fiona Empig, Cyril Kenner, Julie Jobes, David
Source	Elsevier; Medline; PMC
abstract	Abstract The frequency of moderate to severe adverse reactions associated with smallpox vaccines currently stockpiled in the US, and the continued threat of bioterrorism have prompted the development of effective vaccines with improved safety profiles. LC16m8, an attenuated, replicating smallpox vaccine derived from the Lister strain of vaccinia, is currently licensed in Japan where it was safely used in over 50,000 children in the 1970s. It has been shown to have markedly less neurotoxicity than unattenuated vaccines in nonclinical studies. LC16m8 is immunogenic after a single dose, and recent studies in two different animal models have demonstrated protective efficacy equivalent to that of the only FDA-licensed smallpox vaccine. This article reviews the history and available scientific literature regarding LC16m8 and provides comparisons to other smallpox vaccines.
has issue date	2006-11-17(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2006.03.087
bibo:pmid	17052815
has license	els-covid
sha1sum (hex)	57570091beaa720453406818912b8a7cb2f56fa0
schema:url	https://doi.org/10.1016/j.vaccine.2006.03.087
resource representing a document's title	LC16m8: An attenuated smallpox vaccine
has PubMed Central identifier	PMC7115618
has PubMed identifier	17052815
schema:publication	Vaccine
resource representing a document's body	covid:57570091beaa720453406818912b8a7cb2f56fa0#body_text
is schema:about of	named entity 'SMALLPOX VACCINE' named entity 'IMMUNOGENIC' named entity 'PROVIDES' named entity 'RECENT' named entity 'HISTORY' named entity 'LC16M8' named entity 'DEVELOPMENT' named entity 'REPLICATING' named entity 'STRAIN' named entity 'EQUIVALENT' named entity 'CONTINUED' named entity 'EFFECTIVE' named entity 'SMALLPOX VACCINE' named entity 'DERIVED' named entity 'CURRENTLY' named entity 'DIFFERENT' named entity 'LICENSED' named entity 'HAVE' named entity 'SINGLE' named entity 'ARTICLE' named entity 'VACCINIA' named entity 'SMALLPOX VACCINES' named entity 'IMPROVED' named entity 'JAPAN' named entity 'LISTER' named entity 'THREAT' named entity 'SAFETY' named entity 'MARKEDLY' named entity 'DEMONSTRATED' named entity 'ASSOCIATED WITH' named entity 'STUDIES' named entity 'REVIEWS' named entity 'PROMPTED' named entity 'ATTENUATED' named entity 'USED' named entity 'CHILDREN' named entity 'ATTENUATED' named entity 'LC16M8' named entity 'EFFICACY' named entity 'SCIENTIFIC LITERATURE' named entity 'NEUROTOXICITY' named entity 'VACCINES' named entity 'ADVERSE REACTIONS' named entity 'MODERATE TO SEVERE' named entity 'AVAILABLE' named entity 'FREQUENCY' named entity '50%' named entity 'WHERE' named entity 'ANIMAL MODELS ' named entity 'DOSE' named entity 'BIOTERRORISM' covid:arg/57570091beaa720453406818912b8a7cb2f56fa0 named entity 'Japan' named entity 'adverse reactions' named entity 'smallpox vaccine' named entity 'smallpox vaccine' named entity 'animal models' named entity 'vaccinia' named entity 'immunogenic' named entity 'attenuated smallpox' named entity 'immune responses' named entity 'Lister' named entity 'cross-protective immunity' named entity 'vaccinia' named entity 'mammalian cells' named entity 'Lethal Dose 50' named entity 'inoculation' named entity 'adverse reactions' named entity 'MRC-5' named entity 'vaccine' named entity 'immunosuppressed' named entity 'vaccine' named entity 'animal studies' named entity 'Humoral immune responses' named entity 'viral replication' named entity 'progressive vaccinia' named entity 'biodefense'

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