About: Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission
Creator	Gu, Xun Shen, Libing Zhang, Zhao
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to beta group of coronavirus and was first discovered in 2012. MERS-CoV can infect multiple host species and cause severe diseases in human. We conducted a series of phylogenetic and bioinformatic analyses to study the evolution dynamics of MERS-CoV among different host species with genomic data. Our analyses show: 1) 28 potential recombinant sequences were detected and they can be classified into seven potential recombinant types; 2) The spike (S) protein of MERS-CoV was under strong positive selection when MERS-CoV transmitted from their natural host to human; 3) Six out of nine positive selection sites detected in spike (S) protein are located in its receptor-binding domain which is in direct contact with host cells; 4) MERS-CoV frequently transmitted back and forth between human and camel after it had acquired the human-camel infection capability. Together, these results suggest that potential recombination events might have happened frequently during MERS-CoV’s evolutionary history and the positive selection sites in MERS-CoV’s S protein might enable it to infect human.
has issue date	2016-05-04(xsd:dateTime)
bibo:doi	10.1038/srep25049
bibo:pmid	27142087
has license	cc-by
sha1sum (hex)	576bad43bf08b1a2d302695f5624a77fdbcaf6d0
schema:url	https://doi.org/10.1038/srep25049
resource representing a document's title	Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission
has PubMed Central identifier	PMC4855236
has PubMed identifier	27142087
schema:publication	Sci Rep
resource representing a document's body	covid:576bad43bf08b1a2d302695f5624a77fdbcaf6d0#body_text
is schema:about of	named entity 'Transmission' named entity 'RECOMBINATION' named entity 'INFECT' named entity 'DETECTED' named entity 'SEVEN' named entity 'STRONG POSITIVE' named entity 'RECOMBINANT' named entity 'EVOLUTION' named entity 'STUDY' named entity 'CAUSE' named entity 'OUR' named entity 'GENOMIC DATA' named entity 'SEVERE' named entity 'SEQUENCES' named entity 'DISEASES IN HUMAN' named entity 'POSITIVE SELECTION' named entity 'MERS-COV' named entity 'SPIKE' named entity 'MULTIPLE' named entity 'CLASSIFIED' named entity 'POTENTIAL' named entity 'PROTEIN ' named entity 'DIFFERENT' named entity 'OPEN' named entity 'EVOLUTIONARY DYNAMICS' named entity 'TRANSMISSION' named entity 'POSITIVE SELECTION' named entity 'POTENTIAL' named entity '28S' named entity 'DYNAMICS' named entity 'MERS- COV' named entity 'TYPES' named entity 'SERIES' named entity 'HOST SPECIES' named entity 'BIOINFORMATIC' named entity 'divergence' named entity 'Positive selection' named entity 'bat' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'South Korea' named entity 'whole-genome' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'glycoprotein' named entity 'Saudi Arabia' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'positive selection' named entity 'bat' named entity 'receptor binding domain' named entity 'conducted' named entity 'species' named entity 'hedgehog' named entity 'civet' named entity 'infection' named entity 'receptor binding domain' named entity 'transmissibility' named entity 'MERS-CoV' named entity 'Saudi Arabia' named entity 'tMRCA' named entity 'C-terminal' named entity 'MCC' named entity 'nucleotide substitution' named entity 'bat' named entity 'nucleotide substitution' named entity 'type 2' named entity 'MERS-CoV' named entity 'evolutionary dynamics' named entity 'Rhinolophus ferrumequinum' named entity 'c-terminal' named entity 'Vespertilio superans' named entity 'random sampling' named entity 'hedgehog' named entity 'S protein' named entity 'clade' named entity 'clade' named entity 'Clade' named entity 'European hedgehog'

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