About: Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)

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About: Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)
Creator	Miazgowicz, Kerri Munster, Vincent Hawkinson, Ann Schountz, Tony Bushmaker, Trenton Scott, Dana Bowen, Richard Milne-Price, Shauna Rosenke, Rebecca Adney, Danielle De Wit, Emmie Van Doremalen, Neeltje Brown, Vienna
Source	Medline; PMC
abstract	The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential of Betacoronaviruses. Investigations into the origin of MERS-CoV have focused on two potential reservoirs: bats and camels. Here, we investigated the role of bats as a potential reservoir for MERS-CoV. In vitro, the MERS-CoV spike glycoprotein interacted with Jamaican fruit bat (Artibeus jamaicensis) dipeptidyl peptidase 4 (DPP4) receptor and MERS-CoV replicated efficiently in Jamaican fruit bat cells, suggesting there is no restriction at the receptor or cellular level for MERS-CoV. To shed light on the intrinsic host-virus relationship, we inoculated 10 Jamaican fruit bats with MERS-CoV. Although all bats showed evidence of infection, none of the bats showed clinical signs of disease. Virus shedding was detected in the respiratory and intestinal tract for up to 9 days. MERS-CoV replicated transiently in the respiratory and, to a lesser extent, the intestinal tracts and internal organs; with limited histopathological changes observed only in the lungs. Analysis of the innate gene expression in the lungs showed a moderate, transient induction of expression. Our results indicate that MERS-CoV maintains the ability to replicate in bats without clinical signs of disease, supporting the general hypothesis of bats as ancestral reservoirs for MERS-CoV.
has issue date	2016-02-22(xsd:dateTime)
bibo:doi	10.1038/srep21878
bibo:pmid	26899616
has license	cc-by
sha1sum (hex)	577c6a13f9ef70e9756890fc66e98f537c01ac0a
schema:url	https://doi.org/10.1038/srep21878
resource representing a document's title	Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)
has PubMed Central identifier	PMC4761889
has PubMed identifier	26899616
schema:publication	Sci Rep
resource representing a document's body	covid:577c6a13f9ef70e9756890fc66e98f537c01ac0a#body_text
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