About: Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France
Creator	Pontier, Dominique Sauvage, Frank Castel, Guillaume Tordo, Noël Pons, Jean-Baptiste Marianneau, Philippe Cosson, Jean-François Couteaudier, Mathilde Murri, Séverine Plyusnin, Alexander Plyusnina, Angelina
source	PMC
abstract	Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing piece of the puzzle is the current distribution and the genetic variation of PUUV in France, which has been overlooked until now and remains poorly understood. During a population survey, from 2008 to 2011, bank voles were trapped in eight different forests of France located in areas known to be endemic for NE or in area from where no NE case has been reported until now. Bank voles were tested for immunoglobulin (Ig)G ELISA serology and two seropositive animals for each of three different areas (Ardennes, Jura and Orleans) were then subjected to laboratory analyses in order to sequence the whole S, M and L segments of PUUV. Phylogenetic analyses revealed that French PUUV isolates globally belong to the central European (CE) lineage although isolates from Ardennes are clearly distinct from those in Jura and Orleans, suggesting a different evolutionary history and origin of PUUV introduction in France. Sequence analyses revealed specific amino acid signatures along the N protein, including in PUUV from the Orleans region from where NE in humans has never been reported. The relevance of these mutations in term of pathophysiology is discussed.
has issue date	2015-10-22(xsd:dateTime)
bibo:doi	10.3390/v7102884
bibo:pmid	26506370
has license	cc-by
sha1sum (hex)	578ad49441884c636eb9d6044237708eb6437afb
schema:url	https://doi.org/10.3390/v7102884
resource representing a document's title	Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France
has PubMed Central identifier	PMC4632392
has PubMed identifier	26506370
schema:publication	Viruses
resource representing a document's body	covid:578ad49441884c636eb9d6044237708eb6437afb#body_text
is schema:about of	named entity 'Genome' named entity 'WORK' named entity 'CIRCULATING' named entity 'AUTHORS' named entity 'PHYLOGENY' named entity 'PUUMALA HANTAVIRUS' named entity 'ISOLATES' named entity 'COMPLETE' named entity 'GENOME' named entity 'FRANCE' named entity 'THESE' named entity 'France' named entity 'PUUV' named entity 'PUUV' named entity 'Ardennes' named entity 'Europe' named entity 'Belgium' named entity 'PUUV' named entity 'France' named entity 'PUUV' named entity 'Ardennes' named entity 'hantaviruses' named entity 'vectors' named entity 'hyper variable region' named entity 'Jura' named entity 'reassortment' named entity 'amino acid residues' named entity 'viruses' named entity 'hantavirus' named entity 'heterogeneity' named entity 'PUUV' named entity 'open reading frame' named entity 'protein' named entity 'rodent' named entity 'RNA genome' named entity 'PUUV' named entity 'Antarctica' named entity 'endemic' named entity 'sequence alignments' named entity 'amino acid' named entity 'RT-PCR' named entity 'rodents' named entity 'genetic differences' named entity 'infection' named entity 'virulence' named entity 'GenBank' named entity 'PUUV' named entity 'nucleocapsid protein' named entity 'genetic variability' named entity 'PUUV' named entity 'Q64' named entity 'protein' named entity 'gene' named entity 'pathologies' named entity 'consensus sequence' named entity 'endemic' named entity 'PUUV' named entity 'seropositive' named entity 'Germany' named entity 'Rodent' named entity 'agarose gel' named entity 'Ardennes' named entity 'bank voles' named entity 'nucleotide' named entity 'rodent' named entity 'PUUV' named entity 'PUUV' named entity 'amino acid residues' named entity 'pathogenesis' named entity 'rodent' named entity 'PUUV'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software