About: Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance
Creator	Coombs, Kevin Meyer, Florencia Glover, Kathleen Sher, Affan
source	PMC
abstract	The first human Zika virus (ZIKV) outbreak was reported in Micronesia in 2007, followed by one in Brazil in 2015. Recent studies have reported cases in Europe, Oceania and Latin America. In 2016, ZIKV transmission was also reported in the US and the World Health Organization declared it a Public Health Emergency of International Concern. Because various neurological conditions are associated with ZIKV, such as microcephaly, Guillain-Barré syndrome, and other disorders of both the central and peripheral nervous systems, including encephalopathy, (meningo)encephalitis and myelitis, and because of the lack of reliable patient diagnosis, numerous ongoing studies seek to understand molecular mechanisms underlying ZIKV pathogenesis. Astrocytes are one of the most abundant cells in the CNS. They control axonal guidance, synaptic signaling, neurotransmitter trafficking and maintenance of neurons, and are targeted by ZIKV. In this study, we used a newly developed multiplexed aptamer-based technique (SOMAScan) to examine > 1300 human astrocyte cell proteins. We identified almost 300 astrocyte proteins significantly dysregulated by ZIKV infection that span diverse functions and signaling pathways, including protein translation, synaptic control, cell migration and differentiation.
has issue date	2019-03-26(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.00596
bibo:pmid	30984137
has license	cc-by
sha1sum (hex)	5794890e355a8abbec51b46d767b6ee67edcd274
schema:url	https://doi.org/10.3389/fmicb.2019.00596
resource representing a document's title	Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance
has PubMed Central identifier	PMC6448030
has PubMed identifier	30984137
schema:publication	Front Microbiol
resource representing a document's body	covid:5794890e355a8abbec51b46d767b6ee67edcd274#body_text
is schema:about of	named entity 'CONTROL' named entity 'ABUNDANT' named entity '2C CELL' named entity 'TRAFFICKING' named entity 'ASSOCIATED WITH' named entity 'VARIOUS' named entity 'HUMAN' named entity 'MAINTENANCE' named entity 'AXONAL GUIDANCE' named entity 'ONE OF' named entity 'MYELITIS' named entity 'STUDIES' named entity 'DIVERSE' named entity 'PATIENT DIAGNOSIS' named entity 'APTAMER' named entity 'LACK' named entity 'NEURONS' named entity 'SIGNALING PATHWAYS' named entity 'CNS' named entity 'UNDERLYING' named entity 'MICROCEPHALY' named entity 'SYNDROME' named entity 'TECHNIQUE' named entity 'MOLECULAR' named entity 'INCLUDING' named entity 'BASED' named entity 'TARGETED' named entity 'DISORDERS' named entity 'ENCEPHALOPATHY' named entity 'DIFFERENTIATION' named entity 'ZIKA VIRUS INFECTION' named entity 'BARR' named entity 'CONDITIONS' named entity 'ASTROCYTES' named entity 'PROTEINS' named entity 'NEWLY' named entity 'NUMEROUS' named entity 'ASTROCYTIC' named entity 'SYNAPSE' named entity 'INVOLVED' named entity 'AXON GUIDANCE' named entity 'DISRUPTS' named entity 'SPAN' named entity 'USED' named entity 'CELLS' named entity 'SYNAPTIC SIGNALING' named entity 'STUDY' named entity 'ASTROCYTE' named entity 'ZIKV' named entity 'ALMOST' named entity 'CELL MIGRATION' named entity 'CENTRAL' named entity 'MECHANISMS' named entity '1300' named entity 'CONTROL' named entity 'UNDERSTAND' named entity 'CONCERN' named entity 'IDENTIFIED' named entity 'NEUROLOGICAL' named entity 'RELIABLE' named entity 'PROTEIN TRANSLATION' named entity 'PATHOGENESIS' named entity 'TO EXAMINE' named entity '300' named entity 'CELL' named entity 'FUNCTIONS' named entity 'NEUROTRANSMITTER' named entity 'PROTEINS' named entity 'ONGOING' named entity 'PERIPHERAL NERVOUS SYSTEMS' named entity 'aptamer' named entity 'protein translation' named entity 'encephalopathy' named entity 'ZIKV' named entity 'infection' named entity 'axonal guidance' named entity 'SOMAScan' named entity 'Astrocytic'

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