About: A novel intracellularly expressed NS5B-specific nanobody suppresses bovine viral diarrhea virus replication

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About: A novel intracellularly expressed NS5B-specific nanobody suppresses bovine viral diarrhea virus replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A novel intracellularly expressed NS5B-specific nanobody suppresses bovine viral diarrhea virus replication
Creator	Xiao, Shuqi Duan, Hong Li, Zhiwei Ma, Zhiqian Xu, Lele Zhang, Angke
topic	covid:57b1179e96db85fd18f30239d8370fe6c3d4c0c6#this
Source	Elsevier; Medline; PMC
abstract	Bovine viral diarrhea virus (BVDV) infection causes significant economic losses to the cattle industry worldwide and still represents a huge pressure on agricultural production. Thus, the development of novel anti-BVDV strategies are urgently needed. The nonstructural protein 5 (NS5B) of BVDV is essential for viral replication. Further, the camel single-domain antibody (nanobody) represents a promising antiviral approach with the advantages of small size, stable structure, high specificity and solubility, and the recognition of specific epitopes. However, no NS5B-specific nanobodies against BVDV have been reported. In this study, NS5B-specific nanobodies were isolated from a phage display library of variable domains of Camellidae heavy chain-only antibodies (VHHs). Further, an MDBK cell line stably expressing Nb1 was established to explore antiviral activity. Results showed that Nb1 could markedly suppress BVDV replication and interact with the BVDV NS5B protein. This suggests that nanobodies have potential for the development of novel antiviral drugs against BVDV infection.
has issue date	2019-10-12(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2019.108449
bibo:pmid	31836380
has license	no-cc
sha1sum (hex)	57b1179e96db85fd18f30239d8370fe6c3d4c0c6
schema:url	https://doi.org/10.1016/j.vetmic.2019.108449
resource representing a document's title	A novel intracellularly expressed NS5B-specific nanobody suppresses bovine viral diarrhea virus replication
has PubMed Central identifier	PMC7117317
has PubMed identifier	31836380
schema:publication	Vet Microbiol
resource representing a document's body	covid:57b1179e96db85fd18f30239d8370fe6c3d4c0c6#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/57b1179e96db85fd18f30239d8370fe6c3d4c0c6
is schema:about of	named entity 'CAUSES' named entity 'RESULTS' named entity 'STUDY' named entity 'ECONOMIC' named entity 'SMALL SIZE' named entity 'SOLUBILITY' named entity 'PROTEIN ' named entity 'ANTIBODY' named entity 'NEEDED' named entity 'SUPPRESS' named entity 'INTERACT' named entity 'activity' named entity 'high' named entity 'virus' named entity 'NANOBODY' named entity 'BOVINE VIRAL DIARRHEA VIRUS' named entity 'INFECTION' named entity 'SPECIFICITY' named entity 'WORLDWIDE' named entity 'ANTIVIRAL' named entity 'SINGLE' named entity 'DEVELOPMENT' named entity 'NS5B' named entity 'ANTIVIRAL DRUGS' named entity 'CAMEL' named entity 'DOMAIN' named entity 'RECOGNITION' named entity 'PHAGE DISPLAY LIBRARY' named entity 'POTENTIAL' named entity 'STRATEGIES' named entity 'SUPPRESSES' named entity 'EXPRESSED' named entity 'NS5B' named entity 'VIRUS REPLICATION' named entity 'BOVINE VIRAL DIARRHEA VIRUS' named entity 'AGRICULTURAL PRODUCTION' named entity 'SIGNIFICANT' named entity 'CATTLE INDUSTRY' named entity 'HIGH' named entity 'STRUCTURE' named entity 'HEAVY CHAIN' named entity 'NOVEL' named entity 'NOVEL' named entity 'SPECIFIC' named entity 'HUGE' named entity 'NB1' named entity 'STABLE' named entity 'MARKEDLY' named entity 'ESSENTIAL' named entity 'REPORTED' named entity 'REPLICATION' named entity 'APPROACH' named entity 'CELL LINE' named entity 'HAVE' named entity 'ESTABLISHED' named entity 'MDBK CELL' named entity 'PRESSURE' named entity 'VARIABLE' named entity 'ANTIBODIES' named entity 'EPITOPES' named entity 'ANTIVIRAL ACTIVITY' named entity 'SPECIFIC' named entity 'VIRAL REPLICATION' named entity 'ISOLATED' covid:arg/57b1179e96db85fd18f30239d8370fe6c3d4c0c6 named entity 'antiviral' named entity 'antibodies' named entity 'explore' named entity 'potential' named entity 'variable' named entity 'Nb1' named entity 'antiviral drugs' named entity 'promising' named entity 'bovine viral diarrhea'

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