About: Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins

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About: Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins
Creator	Ganapathy, Radha Huan, Lifang Sundararajan, Aarthi Webby, Richard Sangster, Mark Dunlap, John Kotwal, Girish
Source	Elsevier; Medline; PMC
abstract	Abstract Pomegranates have high levels of polyphenols (PPs) and may be a rich source of compounds with antiviral activity. We evaluated the direct anti-influenza activity of three commercially available pomegranate extracts: pomegranate juice (PJ), a concentrated liquid extract (POMxl), and a 93% PP powder extract (POMxp). The acidity of PJ and POMxl solutions contributed to rapid anti-influenza activity, but this was not a factor with POMxp. Studies using POMxp showed that 5min treatment at room temperature with 800μg/ml PPs resulted in at least a 3log reduction in the titers of influenza viruses PR8 (H1N1), X31 (H3N2), and a reassortant H5N1 virus derived from a human isolate. However, the antiviral activity was less against a coronavirus and reassortant H5N1 influenza viruses derived from avian isolates. The loss of influenza infectivity was frequently accompanied by loss of hemagglutinating activity. PP treatment decreased Ab binding to viral surface molecules, suggesting some coating of particles, but this did not always correlate with loss of infectivity. Electron microscopic analysis indicated that viral inactivation by PPs was primarily a consequence of virion structural damage. Our findings demonstrate that the direct anti-influenza activity of pomegranate PPs is substantially modulated by small changes in envelope glycoproteins.
has issue date	2010-10-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2010.06.014
bibo:pmid	20637243
has license	els-covid
sha1sum (hex)	57b4939fbcc081a9bf7730c344c1c3218651c0b7
schema:url	https://doi.org/10.1016/j.antiviral.2010.06.014
resource representing a document's title	Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins
has PubMed Central identifier	PMC7114265
has PubMed identifier	20637243
schema:publication	Antiviral Research
resource representing a document's body	covid:57b4939fbcc081a9bf7730c344c1c3218651c0b7#body_text
is schema:about of	named entity 'virus' named entity 'influenza virus' named entity 'l-glutamine' named entity 'virion' named entity 'H5N1' named entity 'host cell' named entity 'hen's eggs' named entity 'influenza' named entity 'H1N1' named entity 'virion' named entity 'MDCK' named entity 'chicken' named entity 'gastrointestinal tract' named entity 'colorimetric determination' named entity 'ATCC' named entity 'RBC' named entity 'influenza A virus' named entity 'free culture' named entity 'virus' named entity 'sialic acids' named entity 'RBCs' named entity 'polyphenolic compounds' named entity 'morbidity' named entity 'RBCs' named entity 'MDCK' named entity 'infectivity' named entity 'influenza virus' named entity 'reagent' named entity 'RBC' named entity 'control experiments' named entity 'pomegranate' named entity 'United states' named entity 'H1N1' named entity 'room temperature' named entity 'influenza viruses' named entity 'viral particles' named entity 'culture medium' named entity 'California' named entity 'MDCK' named entity 'influenza viruses' named entity 'antiviral activity' named entity 'influenza viruses' named entity 'absorbance' named entity 'titer' named entity 'goat' named entity 'allantoic cavity' named entity 'A59' named entity 'infectivity' named entity 'intracellular' named entity 'PBS' named entity 'virions' named entity 'cell culture medium' named entity 'selective pressure' named entity 'absorbance' named entity 'antiviral activity' named entity 'anti-influenza' named entity 'reassortant' named entity 'influenza' named entity 'viral particles' named entity 'titration' named entity 'glycoproteins' named entity 'Virus' named entity 'cellular level' named entity 'influenza virus' named entity 'electron microscopy' named entity 'BSA' named entity 'anti-influenza' named entity 'selective pressure' named entity 'PBS' named entity 'antiviral activity' named entity 'titration' named entity 'coronavirus' named entity 'influenza' named entity 'cell surface molecules' named entity 'virus'

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