About: Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways
Creator	Li, Yinghua Deng, Ning Lin, Zhengfang Wang, Changbing Xu, Tiantian Zhao, Mingqi Zhu, Bing
source	Medline; PMC
abstract	Recently, silver nanoparticles (AgNPs) have been shown to provide a novel approach to overcome tumors, especially those of hepatocarcinoma. However, the anticancer mechanism of silver nanoparticles is unclear. Thus, the purpose of this study was to estimate the effect of AgNPs on proliferation and activation of ROS-mediated signaling pathway on human hepatocellular carcinoma HePG-2 cells. A simple chemical method for preparing AgNPs with superior anticancer activity has been showed in this study. AgNPs were detected by transmission electronic microscopy (TEM) and energy dispersive X-ray (EDX). The size distribution and zeta potential of silver nanoparticles were detected by Zetasizer Nano. The average size of AgNPs (2 nm) observably increased the cellular uptake by endocytosis. AgNPs markedly inhibited the proliferation of HePG-2 cells through induction of apoptosis with caspase-3 activation and PARP cleavage. AgNPs with dose-dependent manner significantly increased the apoptotic cell population (sub-G1). Furthermore, AgNP-induced apoptosis was found dependent on the overproduction of reactive oxygen species (ROS) and affecting of MAPKs and AKT signaling and DNA damage-mediated p53 phosphorylation to advance HePG-2 cells apoptosis. Therefore, our results show that the mechanism of ROS-mediated signaling pathways may provide useful information in AgNP-induced HePG-2 cell apoptosis.
has issue date	2016-04-14(xsd:dateTime)
bibo:doi	10.1186/s11671-016-1419-4
bibo:pmid	27075340
has license	cc-by
sha1sum (hex)	57b8e034f902f2883dbbafaeef554cb2deb64963
schema:url	https://doi.org/10.1186/s11671-016-1419-4
resource representing a document's title	Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways
has PubMed Central identifier	PMC4830774
has PubMed identifier	27075340
schema:publication	Nanoscale Res Lett
resource representing a document's body	covid:57b8e034f902f2883dbbafaeef554cb2deb64963#body_text
is schema:about of	named entity 'estimate' named entity 'hepatocarcinoma' named entity 'silver nanoparticles' named entity 'PARP' named entity 'APOPTOSIS' named entity 'ROS' named entity 'CASPASE-3 ACTIVATION' named entity 'DETECTED' named entity 'ADVANCE' named entity 'UNCLEAR' named entity 'HAVE' named entity 'USEFUL INFORMATION' named entity 'SIZE DISTRIBUTION' named entity 'CELLS' named entity 'CLEAVAGE' named entity 'ZETA POTENTIAL' named entity 'APOPTOSIS' named entity 'ACTIVITY' named entity 'ESTIMATE' named entity 'TO PROVIDE' named entity 'HEPATOCELLULAR CARCINOMA' named entity 'MARKEDLY' named entity 'SIGNALING PATHWAY' named entity 'DNA DAMAGE' named entity 'SILVER NANOPARTICLES' named entity 'SIGNALING PATHWAYS' named entity 'PURPOSE' named entity 'RESULTS' named entity 'ANTICANCER' named entity 'HUMAN' named entity 'PREPARING' named entity 'APOPTOTIC CELL' named entity 'SIZE' named entity 'TUMORS' named entity 'P53' named entity 'RECENTLY' named entity 'STUDY' named entity 'NANO' named entity 'MECHANISM' named entity 'AKT SIGNALING' named entity 'HEPATOCARCINOMA' named entity 'SIGNALING PATHWAYS' named entity 'OVERCOME' named entity 'SIMPLE CHEMICAL' named entity 'INCREASED' named entity 'REACTIVE OXYGEN SPECIES' named entity 'ELECTRONIC' named entity 'DEPENDENT' named entity 'EFFECT' named entity 'INHIBITED' named entity 'MICROSCOPY' named entity 'X-RAY' named entity 'MEDIATED' named entity 'CELLS' named entity 'SILVER NANOPARTICLES' named entity 'INDUCE' named entity 'AFFECTING' named entity 'SUPERIOR' named entity 'PROVIDE' named entity 'ROS' named entity 'AVERAGE' named entity 'ENDOCYTOSIS' named entity 'MEDIATED' named entity 'MAPKS' named entity '282' named entity 'OUR' named entity 'DOSE-DEPENDENT' named entity 'INDUCTION OF APOPTOSIS' named entity 'APPROACH' named entity 'PROLIFERATION' named entity 'FOUND' named entity 'ZETASIZER' named entity 'NOVEL' named entity 'CELL POPULATION' named entity 'ENERGY'

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