About: Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies
Creator	Wang, Hua Li, Yangyang Shi, Xuanling Wang, Han Zhou, Panpan Zhou, Tongqing Fang, Mengqi Li, Zihao Shang, Hong Shi, Shasha Wu, Jiapeng Hanid, Xiaoxu Zhangid, Linqi
topic	covid:57eb57853f082c4b343cb136c248c9b14f5e632c#this
source	PMC
abstract	Recently identified broadly neutralizing antibodies (bnAbs) show great potential for clinical interventions against HIV-1 infection. However, resistant strains may impose substantial challenges. Here, we report on the identification and characterization of a panel of HIV-1 strains with broad and potent resistance against a large number of bnAbs, particularly those targeting the CD4-binding site (CD4bs). Site-directed mutagenesis revealed that several key epitope mutations facilitate resistance and are located in the inner domain, loop D, and β23/loop V5/β24 of HIV-1 gp120. The resistance is largely correlated with binding affinity of antibodies to the envelope trimers expressed on the cell surface. Our results therefore demonstrate the existence of broadly resistant HIV-1 strains against CD4bs neutralizing antibodies. Treatment strategies based on the CD4bs bnAbs must overcome such resistance to achieve optimal clinical outcomes.
has issue date	2019-06-13(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1007819
bibo:pmid	31194843
has license	cc0
sha1sum (hex)	57eb57853f082c4b343cb136c248c9b14f5e632c
schema:url	https://doi.org/10.1371/journal.ppat.1007819
resource representing a document's title	Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies
has PubMed Central identifier	PMC6592578
has PubMed identifier	31194843
schema:publication	PLoS Pathog
resource representing a document's body	covid:57eb57853f082c4b343cb136c248c9b14f5e632c#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/57eb57853f082c4b343cb136c248c9b14f5e632c
is schema:about of	named entity 'NEUTRALIZING ANTIBODIES' named entity 'strains' named entity 'CD4' named entity 'neutralizing antibodies' named entity 'RESISTANT' named entity 'HIV-1' named entity 'OPTIMAL' named entity 'CD4' named entity 'HIV-1' named entity 'CHARACTERIZATION' named entity 'GREAT' named entity 'NEUTRALIZING ANTIBODIES' named entity 'BROADLY NEUTRALIZING ANTIBODIES' named entity 'IDENTIFIED' named entity 'ANTIBODIES' named entity 'RESISTANCE' named entity 'MUTATIONS' named entity 'PANEL' named entity 'LARGE' named entity 'STRATEGIES' named entity 'EPITOPE' named entity 'BINDING SITE' named entity 'NUMBER OF' named entity 'TREATMENT' named entity 'OUR' covid:arg/57eb57853f082c4b343cb136c248c9b14f5e632c named entity 'BASED' named entity 'CORRELATED' named entity 'CD4' named entity 'THE CELL' named entity 'OVERCOME' named entity 'KEY' named entity 'LOCATED IN' named entity 'BINDING AFFINITY' named entity 'GP120' named entity 'HERE' named entity 'RESISTANCE TO' named entity 'IDENTIFICATION' named entity 'POTENTIAL' named entity 'CLINICAL OUTCOMES' named entity 'SITE-DIRECTED MUTAGENESIS' named entity 'RESULTS' named entity 'HIV-1 INFECTION' named entity 'REPORT' named entity 'TARGETING' named entity 'BROAD' named entity 'RESISTANT' named entity 'BINDING SITE' named entity 'RECENTLY' named entity 'STRAINS' named entity 'EXPRESSED' named entity 'CHALLENGES' named entity 'CELL SURFACE' named entity 'INNER' named entity 'IMPOSE' named entity 'LOOP' named entity 'DOMAIN' named entity 'ENVELOPE' named entity 'REVEALED' named entity 'CLINICAL INTERVENTIONS' named entity 'antibodies' named entity 'trimers' named entity 'strains' named entity 'correlated' named entity 'CD4' named entity 'substantial' named entity 'resistant'

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