About: Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity

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About: Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity
Creator	Inn, Kyung-Soo Cheon, Shinhye Kim, Yeon-Sook Cho, Nam-Hyuk Aigerim, Abdimadiyeva Choi, Ji-Yeob Choi, Myung-Sik Ha, Na-Young Kim, Jin-Hwan Kim, Yuri Min, Chan-Ki Moon, Jae Shin, Hyun Sohn, Kyung
Source	Medline; PMC
abstract	Despite the ongoing spread of MERS, there is limited knowledge of the factors affecting its severity and outcomes. We analyzed clinical data and specimens from fourteen MERS patients treated in a hospital who collectively represent a wide spectrum of disease severity, ranging from mild febrile illness to fatal pneumonia, and classified the patients into four groups based on severity and mortality. Comparative and kinetic analyses revealed that high viral loads, weak antibody responses, and lymphopenia accompanying thrombocytopenia were associated with disease mortality, whereas persistent and gradual increases in lymphocyte responses might be required for effective immunity against MERS-CoV infection. Leukocytosis, primarily due to increased neutrophils and monocytes, was generally observed in more severe and fatal cases. The blood levels of cytokines such as IL-10, IL-15, TGF-β, and EGF were either positively or negatively correlated with disease mortality. Robust induction of various chemokines with differential kinetics was more prominent in patients that recovered from pneumonia than in patients with mild febrile illness or deceased patients. The correlation of the virological and immunological responses with disease severity and mortality, as well as their responses to current antiviral therapy, may have prognostic significance during the early phase of MERS.
has issue date	2016-05-05(xsd:dateTime)
bibo:doi	10.1038/srep25359
bibo:pmid	27146253
has license	cc-by
sha1sum (hex)	58086bd6aa7a845eac58001de931144a3cebd644
schema:url	https://doi.org/10.1038/srep25359
resource representing a document's title	Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity
has PubMed Central identifier	PMC4857172
has PubMed identifier	27146253
schema:publication	Sci Rep
resource representing a document's body	covid:58086bd6aa7a845eac58001de931144a3cebd644#body_text
is schema:about of	named entity 'DISEASE SEVERITY' named entity 'responses' named entity 'generally' named entity 'cytokines' named entity 'responses' named entity 'TGF-β' named entity 'virological' named entity 'loads' named entity 'febrile' named entity 'representing' named entity 'FATAL' named entity 'ACCOMPANYING' named entity 'ROBUST' named entity 'CLASSIFIED' named entity 'PATIENTS' named entity 'TREATED' named entity 'RESPONSES' named entity 'LIMITED' named entity 'PHASE' named entity 'BLOOD' named entity 'LEUKOCYTOSIS' covid:arg/58086bd6aa7a845eac58001de931144a3cebd644 named entity 'CORRELATION' named entity 'DUE TO' named entity 'CLINICAL DATA' named entity 'KNOWLEDGE' named entity 'ASSOCIATED WITH' named entity 'IL-15' named entity 'HIGH' named entity 'MERS' named entity 'VIROLOGICAL' named entity 'OBSERVED' named entity 'KINETIC' named entity 'INDUCTION' named entity 'PATIENTS' named entity 'MIGHT BE' named entity 'OPEN' named entity 'VIRAL SHEDDING' named entity 'MONOCYTES' named entity 'PROGNOSTIC' named entity 'CORRELATED' named entity 'TGF' named entity 'REQUIRED' named entity 'INFECTION' named entity 'WIDE' named entity 'EFFECTIVE' named entity 'DIFFERENTIAL' named entity 'EGF' named entity 'BROAD SPECTRUM' named entity 'MERS' named entity 'ANALYSIS' named entity 'WEAK' named entity 'ITS' named entity 'ANALYZED' named entity 'FEBRILE ILLNESS' named entity '10%' named entity 'IMMUNOLOGICAL' named entity 'SEVERE' named entity 'ONGOING' named entity 'CASES' named entity 'EARLY' named entity 'REPRESENT' named entity 'LYMPHOCYTE' named entity 'GROUPS' named entity 'MILD' named entity 'KINETICS' named entity 'OUTCOMES' named entity 'CYTOKINES'

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