About: Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19

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About: Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19
Creator	Baldus, Niklas Bode, Christoph Busch, Hans-Jörg Duerschmied, Daniel Gauchel, Nadine Goller, Isabella Jeserich, Maren Lother, Achim Pollmeier, Luisa Rieder, Marina Schmid, Bonaventura Supady, · Wirth, Luisa
Source	Medline; PMC
abstract	COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported a markedly increased rate of VTEs in COVID-19. However, most recent studies on coagulopathy in COVID-19 were only focused on critically ill patients, and without suitable control groups. We aimed to evaluate the rate of VTEs in an all-comers cohort with suspected COVID-19 during a 30-days follow-up period. We also studied the level of D-dimers and their association with the course of disease. In our prospective single-center study (DRKS00021206, 03/30/2020), we analyzed 190 patients with suspected COVID-19 admitted to the emergency department between March and April 2020. Forty-nine patients were SARS-CoV-2 positive (25.8%). The 141 SARS-CoV-2-negative patients served as control group. After completion of a 30-days follow-up, VTE was diagnosed in 3 patients of the SARS-CoV-2-positive group (6.1%, amongst these 2 ICU cases) versus 5 patients in the SARS-CoV-2-negative group (3.5%), however the difference was not statistically significant (p = 0.427). 30-days mortality was similar in both groups (6.1% vs. 5%, p = 0.720). Disease severity correlated with the maximum level of D-dimers during follow-up in COVID-19. The rate of VTE was numerically higher in SARS-CoV-2 positive all-comers presenting with suspected COVID-19 as compared to well-matched controls suffering from similar symptoms. VTEs in the COVID-19 group predominantly occurred in ICU courses. The maximum level of D-dimers during follow-up was associated with disease severity in COVID-19, whereas the level of D-dimers at admission was not.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1007/s11239-020-02202-8
bibo:pmid	32617807
has license	cc-by
sha1sum (hex)	5836d83f8fabd45d9fe7abc094939ce2add72015
schema:url	https://doi.org/10.1007/s11239-020-02202-8
resource representing a document's title	Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19
has PubMed Central identifier	PMC7331913
has PubMed identifier	32617807
schema:publication	J Thromb Thrombolysis
resource representing a document's body	covid:5836d83f8fabd45d9fe7abc094939ce2add72015#body_text
is schema:about of	named entity 'Retrospective' named entity 'venous thromboembolism' named entity 'hypoxemia' named entity 'statistically significant' named entity 'suspected' named entity 'prospective' named entity 'clinical complications' named entity 'coagulopathy' named entity 'VTE' named entity 'COVID-19.' named entity 'control groups' named entity 'COVID-19' named entity 'control group' named entity 'Mann-Whitney' named entity 'Wuhan' named entity 'ICU' named entity 'coagulopathy' named entity 'COVID' named entity 'PCR' named entity 'coagulopathy' named entity 'COVID' named entity 'COVID' named entity 'medical history' named entity 'critically ill patients' named entity 'Wuhan' named entity 'SARS-CoV-2' named entity 'statistically significant' named entity 'COVID' named entity 'VTE' named entity 'IBM' named entity 'D-dimer' named entity 'statistically significant' named entity 'invasive ventilation' named entity 'ethics committee' named entity 'invasive ventilation' named entity 'April 2020' named entity 'dimers' named entity 'Fisher's exact test' named entity 'ICU' named entity 'COVID-19 pandemic in Germany' named entity 'emergency medicine' named entity 'Germany' named entity 'follow-up' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Declaration of Helsinki' named entity 'dimers' named entity 'COVID-19' named entity 'dimers' named entity 'Armonk' named entity 'follow-up' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'ICU' named entity 'oncological' named entity 'interquartile range' named entity 'emergency department' named entity 'ICU' named entity 'follow-up' named entity 'SARS-CoV-2' named entity 'non-invasive' named entity 'PCR' named entity 'Gaussian distribution' named entity 'SARS-CoV-2' named entity 'D-dimer' named entity 'Wuhan' named entity 'case-fatality rate' named entity 'control group' named entity 'venous thromboembolism'

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