About: Confirmed central olfactory system lesions on brain MRI in COVID-19 patients with anosmia: a case-series

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Confirmed central olfactory system lesions on brain MRI in COVID-19 patients with anosmia: a case-series
Creator	Pompidou, Georges Chattelier, Gilles De Bonnecaze, Guillaume Escudé, Bernard Gallois, Yoan Girardeau, Yannick Lafont, Clarisse Marx, Mathieu
Source	MedRxiv
abstract	Objective: Anosmia has been listed as a key-symptom associated with the COVID-19 infection. Because it often occurs without any sign of rhinitis, lesions of the central olfactory system have been suspected. To date, however, there is no evidence that anosmia caused by SARS-CoV2 could be the result of brain damage. Methods: We conducted a case-series on 10 consecutive COVID-19 patients who reported anosmia. Each patient prospectively underwent a validated olfactory test (Sniffin Sticks test) and a brain MRI. Results: Hypersignal intensity lesions of the central olfactory system were found in 3 subjects on 3D T2 FLAIR and 2D T2 High Resolution images with a lesion involving the olfactory bulbs and/or the orbitofrontal cortex. These 3 subjects showed a severe and persistent loss of smell on the olfactory test. Mucosal hyperplasia of the upper nasal cavities was found in two other subjects with significant smell disorders. There was no MRI anomaly in two subjects with good smell restoration. Conclusions: Anomalies of the central olfactory system could be responsible for anosmia in patients with COVID-19 infection. Further studies are needed to assess the impact on long-term functional prognosis of these lesions.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1101/2020.07.08.20148692
has license	medrxiv
sha1sum (hex)	58443ec3424680cb19f5c8758a914d7448ef536b
schema:url	https://doi.org/10.1101/2020.07.08.20148692
resource representing a document's title	Confirmed central olfactory system lesions on brain MRI in COVID-19 patients with anosmia: a case-series
resource representing a document's body	covid:58443ec3424680cb19f5c8758a914d7448ef536b#body_text
is schema:about of	named entity 'Case series' named entity 'IMPACT' named entity 'LONG-TERM' named entity 'ASSESS' named entity 'PATIENTS' named entity 'THESE' named entity 'OLFACTORY SYSTEM' covid:arg/58443ec3424680cb19f5c8758a914d7448ef536b named entity 'responsible' named entity 'anosmia' named entity 'assess' named entity 'needed' named entity 'COVID' named entity 'long-term' named entity 'olfactory' named entity 'infection' named entity 'anosmia' named entity 'anosmia' named entity 'olfactory tract' named entity 'SAS' named entity 'olfactory nerves' named entity 'phantosmia' named entity 'MRI' named entity 'olfactory bulb' named entity 'anosmia' named entity 'COVID' named entity 'anosmia' named entity 'brain MRI' named entity 'coronaviruses' named entity 'olfaction' named entity 'brain MRI' named entity 'retroorbital' named entity 'prognosis' named entity 'anosmic' named entity 'rhinitis' named entity 'SARS-CoV2' named entity 'olfactory' named entity 'long-term' named entity 'infection' named entity 'brain MRI' named entity 'SARS-CoV-1' named entity 'loss of sense of smell' named entity 'COVID' named entity 'asthma' named entity 'anosmia' named entity 'anosmia' named entity 'SARS-CoV2' named entity 'hyposmia' named entity 'anosmia' named entity 'epidemic' named entity 'hyposmia' named entity '10/100' named entity 'hyperplasia' named entity 'olfactory' named entity 'epithelium' named entity 'MRI' named entity 'COVID' named entity 'ACE2' named entity 'anosmia' named entity 'rhinitis' named entity 'brain lesions' named entity 'orbitofrontal cortex' named entity 'olfactory epithelium' named entity 'alcohol consumption' named entity 'SARS-CoV2' named entity 'brain MRI' named entity 'olfactory' named entity 'Anosmia' named entity 'SARS-CoV-1' named entity 'orbitofrontal' named entity 'COVID-19' named entity 'anosmia' named entity 'nasal cavity' named entity 'sense of taste' named entity 'epidemic' named entity 'cortical' named entity 'TMPRSS2' named entity 'symptom'

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