About: ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19

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About: ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19
Creator	Aspelund, Thor Emilsson, Valur Gudjonsson, Alexander Gudmundsdottir, Valborg Gudmundsson, Elias Gudnason, Vilmundur Jennings, Lori Jonsson, Brynjolfur Launer, Lenore Lamb, John
Source	MedRxiv; Medline
abstract	Aims: Severity of outcome in COVID-19 is disproportionately higher among the obese, males, smokers, those suffering from hypertension, kidney disease, coronary heart disease (CHD) and/or type 2 diabetes (T2D). We examined if serum levels of ACE2, the cellular entry point for the coronavirus SARS-CoV-2, were altered in these high-risk groups. Methods: Associations of serum ACE2 levels to hypertension, T2D, obesity, CHD, smokers and males in a single center population-based study of 5457 Icelanders from the Age, Gene/Environment Susceptibility Reykjavik Study (AGES-RS) of the elderly (mean age 75+/-6 years). Results: Smokers, males, and individuals with T2D or obesity have altered serum levels of ACE2 that may influence productive infection of SARS-CoV-2 in these high-risk groups. Conclusion: ACE2 levels are upregulated in some patient groups with comorbidities linked to COVID-19 and as such may have an emerging role as a circulating biomarker for severity of outcome in COVID-19.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1101/2020.06.04.20122044
bibo:pmid	32511628
has license	medrxiv
sha1sum (hex)	586b2adbca2c4986b9939604184235b7d6ac080a
schema:url	https://doi.org/10.1101/2020.06.04.20122044
resource representing a document's title	ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19
has PubMed identifier	32511628
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:586b2adbca2c4986b9939604184235b7d6ac080a#body_text
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