About: The Efficacy of Albumin Dialysis in the Reversal of Refractory Vasoplegic Shock Due to Amlodipine Toxicity

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About: The Efficacy of Albumin Dialysis in the Reversal of Refractory Vasoplegic Shock Due to Amlodipine Toxicity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Efficacy of Albumin Dialysis in the Reversal of Refractory Vasoplegic Shock Due to Amlodipine Toxicity
Creator	Patel, M Bridgman, Bob Carr, Jennifer Connor-Schuler, Randi Deepa, ; Reaven, Matthew Subramanian, Ram
Source	PMC
abstract	OBJECTIVES: Calcium channel blockers are highly protein-bound medications frequently used in the management of hypertension. Overdose results in severe hypotension and is the fourth most common cause of toxicity-related deaths in the United States. Management is mostly supportive, with currently no standard role for targeted drug removal. The protein-bound nature of these medications presents the option of utilizing albumin dialysis for their removal and for the reversal of associated shock. DESIGN AND SUBJECTS: We present two cases of life-threatening intentional amlodipine overdoses successfully treated with albumin dialysis. Both patients experienced profound distributive shock in the setting of preserved cardiac contractility that was refractory to maximal vasoactive agent support. INTERVENTIONS AND RESULTS: After initiation of albumin dialysis, the patients showed rapid hemodynamic improvement and were able to be weaned off vasopressor support. CONCLUSIONS: These cases demonstrate the safety and efficacy of albumin dialysis in the management of near-fatal calcium channel blocker overdoses related to amlodipine and offer an additional therapeutic option apart from conventional supportive care. Importantly, these cases were not associated with impaired cardiac contractility, thereby making venoarterial extracorporeal membrane oxygenation a less preferable option. Furthermore, this therapeutic benefit of albumin dialysis can potentially be extended to the management of toxicity related to other highly protein-bound drugs and toxins.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1097/cce.0000000000000120
has license	cc-by-nc-nd
sha1sum (hex)	58935b198ceed267c568c49bc1303a3b629a544e
schema:url	https://doi.org/10.1097/cce.0000000000000120
resource representing a document's title	The Efficacy of Albumin Dialysis in the Reversal of Refractory Vasoplegic Shock Due to Amlodipine Toxicity
has PubMed Central identifier	PMC7314353
schema:publication	Crit Care Explor
resource representing a document's body	covid:58935b198ceed267c568c49bc1303a3b629a544e#body_text
is schema:about of	named entity 'cardiac contractility' named entity 'vasopressor' named entity 'additional' named entity 'Albumin' named entity 'Subjects' named entity 'experienced' named entity 'dialysis' named entity 'patients' named entity 'removal' named entity 'Interventions' named entity 'distributive shock' named entity 'medications' named entity 'therapeutic' named entity 'vasoactive' named entity 'refractory' named entity 'highly' named entity 'overdoses' named entity 'Calcium channel blockers' named entity 'albumin' named entity 'cases' named entity 'dialysis' named entity 'dialysis' named entity 'dialysis' named entity 'amlodipine' named entity 'life-threatening' named entity 'hemodynamic' named entity 'vasopressor' named entity 'hypertension' named entity 'toxicity' named entity 'amlodipine' named entity 'Dialysis' named entity 'toxins' named entity 'albumin' named entity 'insulin' named entity 'liver transplant' named entity 'lactate' named entity 'dialysate' named entity 'Deerfield, IL' named entity 'hemodynamic' named entity 'dialyzed' named entity 'refractory' named entity 'ammonia' named entity 'hepatic encephalopathy' named entity 'vasoactive substances' named entity 'toxicity' named entity 'dialysate' named entity 'fentanyl' named entity 'serum' named entity 'refractory' named entity 'hypokalemia' named entity 'euglycemia' named entity 'charcoal filter' named entity 'liver failure' named entity 'non-dihydropyridine' named entity 'depression' named entity 'acute on chronic' named entity 'antibiotics' named entity 'mm Hg' named entity 'free radical' named entity 'liver failure' named entity 'albumin' named entity 'myocardium' named entity 'Non-dihydropyridine' named entity 'arterial pressure' named entity 'albumin' named entity 'hypoglycemia' named entity 'dialysis' named entity 'midazolam' named entity 'albumin' named entity 'inotropy' named entity 'medical history' named entity 'interleukin-6' named entity 'hepatic' named entity 'cardiac contractility' named entity 'hemodynamic' named entity 'case reports' named entity 'distributive shock'

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