About: The Roles of GRKs in Hemostasis and Thrombosis

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Roles of GRKs in Hemostasis and Thrombosis
Creator	Chen, Xi Cooper, Matthew Ma, Peisong Zhao, Xuefei
source	Medline; PMC
abstract	Along with cancer, cardiovascular and cerebrovascular diseases remain by far the most common causes of death. Heart attacks and strokes are diseases in which platelets play a role, through activation on ruptured plaques and subsequent thrombus formation. Most platelet agonists activate platelets via G protein-coupled receptors (GPCRs), which make these receptors ideal targets for many antiplatelet drugs. However, little is known about the mechanisms that provide feedback regulation on GPCRs to limit platelet activation. Emerging evidence from our group and others strongly suggests that GPCR kinases (GRKs) are critical negative regulators during platelet activation and thrombus formation. In this review, we will summarize recent findings on the role of GRKs in platelet biology and how one specific GRK, GRK6, regulates the hemostatic response to vascular injury. Furthermore, we will discuss the potential role of GRKs in thrombotic disorders, such as thrombotic events in COVID-19 patients. Studies on the function of GRKs during platelet activation and thrombus formation have just recently begun, and a better understanding of the role of GRKs in hemostasis and thrombosis will provide a fruitful avenue for understanding the hemostatic response to injury. It may also lead to new therapeutic options for the treatment of thrombotic and cardiovascular disorders.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.3390/ijms21155345
bibo:pmid	32731360
has license	cc-by
sha1sum (hex)	58a2bf54bbb17d0a157988d3c5657c72094b4094
schema:url	https://doi.org/10.3390/ijms21155345
resource representing a document's title	The Roles of GRKs in Hemostasis and Thrombosis
has PubMed Central identifier	PMC7432802
has PubMed identifier	32731360
schema:publication	Int J Mol Sci
resource representing a document's body	covid:58a2bf54bbb17d0a157988d3c5657c72094b4094#body_text
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