About: Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease(1)(2)(3)

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About: Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease(1)(2)(3) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease(1)(2)(3)
Creator	Adv, Nutr,
Source	Medline; PMC
abstract	The essentiality of zinc in humans was established in 1963. During the past 50 y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed. The major factor contributing to zinc deficiency is high phytate-containing cereal protein intake in the developing world, and nearly 2 billion subjects may be zinc deficient. Conditioned deficiency of zinc has been observed in patients with malabsorption syndrome, liver disease, chronic renal disease, sickle cell disease, and other chronic illnesses. Major clinical problems resulting from zinc deficiency in humans include growth retardation; cell-mediated immune dysfunction, and cognitive impairment. In the Middle East, zinc-deficient dwarfs did not live beyond the age of 25 y, and they died because of intercurrent infections. In 1963, we knew of only 3 enzymes that required zinc for their activities, but now we know of >300 enzymes and >1000 transcription factors that are known to require zinc for their activities. Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling events. Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson’s disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration and is very effective in decreasing the incidence of infection in the elderly. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent.
has issue date	2013-03-01(xsd:dateTime)
bibo:doi	10.3945/an.112.003210
bibo:pmid	23493534
has license	bronze-oa
sha1sum (hex)	58de68bda888e34568a34ed8f23997b3dbedb775
schema:url	https://doi.org/10.3945/an.112.003210
resource representing a document's title	Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease(1)(2)(3)
has PubMed Central identifier	PMC3649098
has PubMed identifier	23493534
schema:publication	Advances in Nutrition
resource representing a document's body	covid:58de68bda888e34568a34ed8f23997b3dbedb775#body_text
is schema:about of	named entity 'ITS' named entity 'sickle cell disease' named entity 'zinc' named entity 'type' named entity 'Impact' named entity 'HEALTH AND DISEASE' named entity 'INFECTION IN THE ELDERLY' named entity 'PHYTATE' named entity 'CELL-MEDIATED IMMUNITY' named entity 'FREE' named entity 'MAJOR' named entity 'BEYOND' named entity 'INTRACELLULAR' named entity 'IMMUNE CELLS' named entity 'NEARLY' named entity 'ZINC' named entity '27S' named entity 'ACUTE DIARRHEA' named entity 'PROTEIN INTAKE' named entity 'TYPE' named entity 'PAST' named entity 'RELATED' named entity 'MALABSORPTION SYNDROME' named entity 'PREVENTION OF' named entity 'ANTI-INFLAMMATORY AGENT' named entity 'EFFECTIVE' named entity 'CLINICAL' named entity 'DISEASE' named entity 'TRANSCRIPTION FACTORS' named entity 'DID' named entity 'ZINC METABOLISM' named entity 'CHRONIC ILLNESSES' named entity 'THESE' named entity 'DEFICIENT' named entity 'DEVELOPING' named entity 'BASIC' named entity 'WORLD' named entity 'COGNITIVE IMPAIRMENT' named entity 'INCIDENCE' named entity 'HUMAN' named entity 'REVIEWS' named entity 'SYMPOSIA' named entity 'CEREAL' named entity 'LIVER DISEASE' covid:arg/58de68bda888e34568a34ed8f23997b3dbedb775 named entity 'DISCOVERY' named entity 'IMMUNE DYSFUNCTION' named entity 'GROWTH RETARDATION' named entity 'CHILDREN' named entity 'THEIR' named entity 'REQUIRED' named entity 'AGE' named entity 'USED' named entity 'MIDDLE EAST' named entity 'BUT' named entity 'ACTIVITIES' named entity 'SECOND MESSENGER' named entity 'THERAPEUTIC' named entity 'MANAGEMENT' named entity 'CHRONIC RENAL DISEASE' named entity 'RESULTING FROM' named entity 'SICKLE CELL DISEASE' named entity 'MEDIATED' named entity 'CONTAINING' named entity 'HIGH' named entity 'PATIENTS' named entity 'INCLUDE' named entity 'MAY BE' named entity 'IMPACT' named entity 'DEFICIENCY OF' named entity 'ANTIOXIDANT' named entity 'MACULAR DEGENERATION' named entity 'ZINC DEFICIENCY' named entity 'MODALITY' named entity 'ZINC DEFICIENCY' named entity 'DWARFS' named entity 'BLINDNESS' named entity 'CELL' named entity 'LIVE' named entity 'PROBLEMS'

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