About: Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L

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About: Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L
Creator	Michiels, Thomas Dé, Fré Silverman, Robert Kant Jha, Babal Sorgeloos, Ric
source	Medline; PMC
abstract	Theiler's virus is a neurotropic picornavirus responsible for chronic infections of the central nervous system. The establishment of a persistent infection and the subsequent demyelinating disease triggered by the virus depend on the expression of L, a viral accessory protein encoded by an alternative open reading frame of the virus. We discovered that L potently inhibits the interferon-inducible OAS/RNase L pathway. The antagonism of RNase L by L* was particularly prominent in macrophages where baseline oligoadenylate synthetase (OAS) and RNase L expression levels are elevated, but was detectable in fibroblasts after IFN pretreatment. L* mutations significantly affected Theiler's virus replication in primary macrophages derived from wild-type but not from RNase L-deficient mice. L* counteracted the OAS/RNase L pathway through direct interaction with the ankyrin domain of RNase L, resulting in the inhibition of this enzyme. Interestingly, RNase L inhibition was species-specific as Theiler's virus L* protein blocked murine RNase L but not human RNase L or RNase L of other mammals or birds. Direct RNase L inhibition by L* and species specificity were confirmed in an in vitro assay performed with purified proteins. These results demonstrate a novel viral mechanism to elude the antiviral OAS/RNase L pathway. By targeting the effector enzyme of this antiviral pathway, L* potently inhibits RNase L, underscoring the importance of this enzyme in innate immunity against Theiler's virus.
has issue date	2013-06-27(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1003474
bibo:pmid	23825954
has license	cc-by
sha1sum (hex)	5908982f4dbbfde0faabcfadc0988b8a19223411
schema:url	https://doi.org/10.1371/journal.ppat.1003474
resource representing a document's title	Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L
has PubMed Central identifier	PMC3694852
has PubMed identifier	23825954
schema:publication	PLoS Pathog
resource representing a document's body	covid:5908982f4dbbfde0faabcfadc0988b8a19223411#body_text
is schema:about of	named entity 'RNASE L' named entity 'neurotropic' named entity 'infection' named entity 'Evasion' named entity 'PATHWAY' named entity 'OPEN READING FRAME' named entity 'VIRUS' named entity 'INDUCIBLE' named entity 'EXPRESSION' named entity 'ALTERNATIVE' named entity 'ESTABLISHMENT' named entity 'PROTEIN ' named entity 'CHRONIC INFECTIONS' named entity 'ACCESSORY PROTEIN' named entity 'INHIBITION' named entity 'PICORNAVIRUS' named entity 'DIRECT' named entity 'TRIGGERED BY' named entity 'RESPONSIBLE' named entity '27S' named entity 'INNATE IMMUNITY' named entity 'PROTEIN ' named entity 'INTERFERON' named entity 'DEPEND' named entity 'NEUROTROPIC' named entity 'ENCODED' named entity 'VIRUS' named entity '27S' named entity 'ANTIVIRAL' named entity 'PERSISTENT INFECTION' named entity 'OAS' named entity 'VIRAL' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'SUBSEQUENT' named entity 'IS A' named entity 'DEMYELINATING DISEASE' named entity 'chronic' named entity 'persistent' named entity 'viral' named entity 'demyelinating disease' named entity 'The establishment' named entity 'interferon' named entity 'RNase' named entity 'central nervous' named entity 'RNase' named entity 'Theiler' named entity 'macrophage' named entity 'viruses' named entity 'TMEV' named entity 'Vaccinia virus' named entity 'endoribonuclease' named entity 'virus' named entity 'EEC' named entity 'capsid' named entity 'co-immunoprecipitation' named entity 'nucleotide' named entity 'immunoblot' named entity 'viral replication' named entity 'Saffold virus' named entity 'quantitative RT-PCR' named entity 'RNA' named entity 'infection' named entity 'HCV' named entity 'macrophages' named entity 'TMEV' named entity 'transduced' named entity 'RNase' named entity 'recombinant' named entity 'cDNA' named entity 'VP1' named entity 'OASL2' named entity 'centrifuged' named entity 'chronic infection' named entity '7.2' named entity 'TMEV' named entity 'mice' named entity 'centrifuged'

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