About: A Simple Methodology for Conversion of Mouse Monoclonal Antibody to Human-Mouse Chimeric Form

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About: A Simple Methodology for Conversion of Mouse Monoclonal Antibody to Human-Mouse Chimeric Form Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A Simple Methodology for Conversion of Mouse Monoclonal Antibody to Human-Mouse Chimeric Form
Creator	Ng, Oi-Wing Tan, Yee-Joo Dang, Vinh Mandakhalikar, Kedar
source	Medline; PMC
abstract	Passive immunotherapy has mainly been used as a therapy against cancer and inflammatory conditions. Recent studies have shown that monoclonal antibody-(mAb-) based passive immunotherapy is a promising approach to combat virus infection. Specific mouse mAbs can be routinely generated in large amounts with the use of hybridoma technology but these cannot be used for therapy in human beings due to their immunogenicity. Therefore, the development of chimeric and humanized mAbs is important for therapeutic purpose. This is facilitated by a variety of molecular techniques like recombinant DNA technology and the better understanding of the structure and function of antibody. The human-mouse chimeric forms allow detailed analysis of the mechanism of inhibition and the potential for therapeutic applications. Here, a step-by-step description of the conversion process will be described. The commercial availability of the reagents required in each step means that this experimentation can be easily set up in research laboratories.
has issue date	2013-09-02(xsd:dateTime)
bibo:doi	10.1155/2013/716961
bibo:pmid	24078817
has license	cc-by
sha1sum (hex)	593d2241563c6bf2e57327ce40e7e83dacbd80fc
schema:url	https://doi.org/10.1155/2013/716961
resource representing a document's title	A Simple Methodology for Conversion of Mouse Monoclonal Antibody to Human-Mouse Chimeric Form
has PubMed Central identifier	PMC3775440
has PubMed identifier	24078817
schema:publication	Clin Dev Immunol
resource representing a document's body	covid:593d2241563c6bf2e57327ce40e7e83dacbd80fc#body_text
is schema:about of	named entity 'potential' named entity 'Here' named entity 'METHODOLOGY' named entity 'MEANS' covid:arg/593d2241563c6bf2e57327ce40e7e83dacbd80fc named entity 'SIMPLE' named entity 'THESE' named entity 'CANCER' named entity 'APPLICATIONS' named entity 'INHIBITION' named entity 'STRUCTURE' named entity 'CONVERSION' named entity 'HUMAN' named entity 'CONVERSION' named entity 'THERAPY' named entity 'HERE' named entity 'DUE TO' named entity 'ALLOW' named entity 'ANTIBODY' named entity 'MECHANISM' named entity 'COMMERCIAL' named entity 'MOLECULAR' named entity 'POTENTIAL' named entity 'REAGENTS' named entity 'CHIMERIC' named entity 'MOUSE MONOCLONAL ANTIBODY' named entity 'FORM' named entity 'THEIR' named entity 'CONDITIONS' named entity 'BETTER' named entity 'DETAILED' named entity 'BASED' named entity 'AMOUNTS' named entity 'APPROACH' named entity 'VIRUS INFECTION' named entity 'BUT' named entity 'TECHNIQUES' named entity 'VARIETY' named entity 'RECOMBINANT DNA TECHNOLOGY' named entity 'EXPERIMENTATION' named entity 'DESCRIPTION' named entity 'TECHNOLOGY' named entity 'FORMS' named entity 'DEVELOPMENT' named entity 'IMMUNOGENICITY' named entity 'USED' named entity 'FOR THERAPY' named entity 'FUNCTION' named entity 'USE OF' named entity 'PASSIVE IMMUNOTHERAPY' named entity 'ANALYSIS' named entity 'STUDIES' named entity 'PROCESS' named entity 'IS A' named entity 'SET UP' named entity 'PURPOSE' named entity 'COMBAT' named entity 'AVAILABILITY OF' named entity 'HYBRIDOMA' named entity 'MONOCLONAL ANTIBODY' named entity 'HUMAN' named entity 'HAVE' named entity 'LIKE' named entity 'REQUIRED' named entity 'LARGE' named entity 'RECENT' named entity 'IMPORTANT' named entity 'DESCRIBED' named entity 'CHIMERIC' named entity 'GENERATED' named entity 'SPECIFIC' named entity 'UNDERSTANDING' named entity 'STEP' named entity 'HUMANIZED' named entity 'MOUSE' named entity 'INFLAMMATORY' named entity 'MOUSE' named entity 'EASILY'

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