About: Complete genome analysis of a SARS-like bat coronavirus identified in the Republic of Korea

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About: Complete genome analysis of a SARS-like bat coronavirus identified in the Republic of Korea Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Complete genome analysis of a SARS-like bat coronavirus identified in the Republic of Korea
Creator	Oem, Jae-Ku Kim, Young-Sik Lee, Sook-Young Jheong, Weonhwa Kim, Yongkwan Son, Kidong
Source	Medline; PMC
abstract	Bats have been widely known as natural reservoir hosts of zoonotic diseases, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) caused by coronaviruses (CoVs). In the present study, we investigated the whole genomic sequence of a SARS-like bat CoV (16BO133) and found it to be 29,075 nt in length with a 40.9% G+C content. Phylogenetic analysis using amino acid sequences of the ORF 1ab and the spike gene showed that the bat coronavirus strain 16BO133 was grouped with the Beta-CoV lineage B and was closely related to the JTMC15 strain isolated from Rhinolophus ferrumequinum in China. However, 16BO133 was distinctly located in the phylogenetic topology of the human SARS CoV strain (Tor2). Interestingly, 16BO133 showed complete elimination of ORF8 regions induced by a frame shift of the stop codon in ORF7b. The lowest amino acid identity of 16BO133 was identified at the spike region among various ORFs. The spike region of 16BO133 showed 84.7% and 75.2% amino acid identity with Rf1 (SARS-like bat CoV) and Tor2 (human SARS CoV), respectively. In addition, the S gene of 16BO133 was found to contain the amino acid substitution of two critical residues (N479S and T487 V) associated with human infection. In conclusion, we firstly carried out whole genome characterization of the SARS-like bat coronavirus discovered in the Republic of Korea; however, it presumably has no human infectivity. However, continuous surveillance and genomic characterization of coronaviruses from bats are necessary due to potential risks of human infection induced by genetic mutation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11262-019-01668-w) contains supplementary material, which is available to authorized users.
has issue date	2019-05-10(xsd:dateTime)
bibo:doi	10.1007/s11262-019-01668-w
bibo:pmid	31076983
has license	no-cc
sha1sum (hex)	5987ebd97819a666092010461148a60bcaf3740d
schema:url	https://doi.org/10.1007/s11262-019-01668-w
resource representing a document's title	Complete genome analysis of a SARS-like bat coronavirus identified in the Republic of Korea
has PubMed Central identifier	PMC7089380
has PubMed identifier	31076983
schema:publication	Virus Genes
resource representing a document's body	covid:5987ebd97819a666092010461148a60bcaf3740d#body_text
is schema:about of	named entity 'BAT CORONAVIRUS' named entity 'substitution' named entity 'spike' named entity 'hosts' named entity 'surveillance' named entity 'MIDDLE EAST RESPIRATORY SYNDROME ' named entity 'RISKS' named entity 'COMPLETE' named entity 'BAT' named entity 'STUDY' named entity 'STRAIN' named entity 'DUE TO' named entity 'CARRIED' named entity 'CAUSED BY' named entity 'RELATED' named entity 'SPIKE' named entity 'FIRSTLY' named entity 'BATS' named entity 'HOSTS' named entity 'VARIOUS' named entity 'ORF8' named entity 'BETA-COV' named entity 'STOP CODON' named entity 'TO CONTAIN' named entity 'INFECTION' named entity 'HAVE' named entity 'CONTINUOUS' named entity 'IDENTIFIED' named entity 'REPUBLIC OF KOREA' named entity 'COMPLETE' named entity 'ELIMINATION' named entity 'SURVEILLANCE' named entity 'RHINOLOPHUS FERRUMEQUINUM' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'IDENTIFIED' named entity 'ORF' named entity 'LOCATED IN' named entity 'AMINO ACID SUBSTITUTION' named entity 'TOPOLOGY' named entity 'INFECTIVITY' named entity 'SARS' named entity 'LIKE' named entity 'HUMAN' named entity 'IDENTITY' named entity 'KNOWN' named entity 'LOWEST' named entity 'GENOMIC' named entity 'GENOME ANALYSIS' named entity 'INFECTION INDUCED' named entity 'WHOLE GENOME' named entity 'GENOMIC SEQUENCE' named entity 'AMINO ACID SEQUENCES' named entity 'NATURAL' named entity 'ORF7B' named entity 'TOR2' named entity 'GENETIC MUTATION' named entity 'CHARACTERIZATION' named entity 'LINEAGE' named entity 'CONTENT' named entity 'SARS' named entity 'GROUPED' named entity 'ASSOCIATED WITH' named entity 'REGION' named entity 'CONCLUSION' named entity 'ISOLATED' named entity 'REPUBLIC OF KOREA' named entity 'BAT CORONAVIRUS' named entity 'RESERVOIR' named entity 'CHINA' named entity 'INVESTIGATED' named entity 'INDUCED' named entity 'PHYLOGENETIC ANALYSIS' named entity 'RF1' named entity 'REGIONS' named entity 'CRITICAL' named entity 'ADDITION'

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