About: Viral security proteins: counteracting host defences

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral security proteins: counteracting host defences
Creator	Gmyl, Anatoly Agol, Vadim Lomonosov, ‡
Source	Medline; PMC
abstract	Interactions with host defences are key aspects of viral infection. Various viral proteins perform counter-defensive functions, but a distinct class, called security proteins, is dedicated specifically to counteracting host defences. Here, the properties of the picornavirus security proteins L and 2A are discussed. These proteins have well-defined positions in the viral polyprotein, flanking the capsid precursor, but they are structurally and biochemically unrelated. Here, we consider the impact of these two proteins, as well as that of a third security protein, L(*), on viral reproduction, pathogenicity and evolution. The concept of security proteins could serve as a paradigm for the dedicated counter-defensive proteins of other viruses. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nrmicro2452) contains supplementary material, which is available to authorized users.
has issue date	2010-11-09(xsd:dateTime)
bibo:doi	10.1038/nrmicro2452
bibo:pmid	21060318
has license	no-cc
sha1sum (hex)	59cbab09b50af6cfb9ce68f304a8b7d85952a008
schema:url	https://doi.org/10.1038/nrmicro2452
resource representing a document's title	Viral security proteins: counteracting host defences
has PubMed Central identifier	PMC7096814
has PubMed identifier	21060318
schema:publication	Nat Rev Microbiol
resource representing a document's body	covid:59cbab09b50af6cfb9ce68f304a8b7d85952a008#body_text
is schema:about of	named entity 'host' named entity 'host' named entity 'PROTEINS' named entity 'IMPACT' named entity 'THESE' named entity 'VIRAL' named entity 'HAVE' named entity 'BUT' named entity 'SECURITY' named entity 'SERVE' named entity 'EVOLUTION' named entity 'VIRAL' named entity 'VIRUSES' named entity 'PICORNAVIRUS' named entity 'POLYPROTEIN' named entity 'HERE' named entity 'HOST' named entity 'HOST' named entity 'FLANKING' named entity 'UNRELATED' named entity 'WELL-DEFINED' named entity 'SECURITY' named entity 'DISTINCT' named entity 'VIRAL PROTEINS' named entity 'PERFORM' named entity 'COUNTER' named entity 'INTERACTIONS' named entity 'VARIOUS' named entity 'CAPSID' named entity 'PARADIGM' named entity 'CLASS' named entity 'CONSIDER' named entity 'DEDICATED' named entity 'FUNCTIONS' named entity 'VIRAL REPRODUCTION' named entity 'PATHOGENICITY' named entity 'PROPERTIES' named entity 'POSITIONS' named entity 'VIRAL INFECTION' named entity 'KEY' named entity 'PRECURSOR' named entity 'PROTEIN' named entity 'PROTEINS' named entity 'CONCEPT' named entity 'called' named entity 'Viral' named entity 'protein' named entity 'capsid' named entity 'polyprotein' named entity 'human diseases' named entity 'hepatitis A virus' named entity 'rodents' named entity 'RNA viruses' named entity 'Picornaviridae' named entity 'Senecavirus' named entity 'virus' named entity 'amino acid' named entity 'VPg' named entity 'Coronaviruses' named entity 'cardiovirus' named entity 'animal virus' named entity 'genomes' named entity 'picorna-like' named entity 'UTRs' named entity 'capsid' named entity 'interferons' named entity 'rhinovirus' named entity 'cytoplasmic' named entity 'virions' named entity 'cardiovirus' named entity 'capsid proteins' named entity 'viruses' named entity 'proteases' named entity 'viruses' named entity 'innate immunity' named entity 'viral reproduction' named entity 'peptide' named entity 'polyprotein' named entity 'non-structural proteins'

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