About: Genotyping of human rhinovirus in adult patients with acute respiratory infections identified predominant infections of genotype A21

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genotyping of human rhinovirus in adult patients with acute respiratory infections identified predominant infections of genotype A21
Creator	Ren, Lili Wang, Jianwei Xiang, Zichun Xiao, Yan Wang, Qi Gao, Zhancheng Li, Mingkun Yang, Donghong Luo, Ming Wang, Ying Jin, Qi Ren, Xianwen Li, Li Fan, Hongwei Hu, Ke Cao, Jie An, Fucheng An, Shuchang Chen, Yusheng Li, Xiangxin Mu, Xinlin Wang, Ruiqin Yan, Chunliang
source	Medline; PMC
abstract	Human rhinovirus (HRV) is an important causative agent of acute respiratory tract infections (ARTIs). The roles of specific HRV genotypes in patients suffering from ARTIs have not been well established. We recruited 147 adult inpatients with community-acquired pneumonia (CAP) and 291 adult outpatients with upper ARTIs (URTIs). Respiratory pathogens were screened via PCR assays. HRV was detected in 42 patients, with 35 species A, five B and two C. Seventeen genotypes were identified, and HRV-A21 ranked the highest (9/42, 21.4%). The HRV-A21-positive infections were detected in four patients with CAP and in five with URTIs, all without co-infections. The HRV-A21 genome sequenced in this study contained 12 novel coding polymorphisms in viral protein (VP) 1, VP2 EF loop, VP3 knob and 3D regions. The infections of HRV-A21 virus obtained in this study could not be neutralized by antiserum of HRV-A21 prototype strain (VR-1131), indicating remarkable antigenic variation. Metagenomic analysis showed the HRV-A21 reads were dominant in bronchoalveolar lavage fluid of the three HRV-A21-positive patients with severe CAP, in which two dead. Our results highlight an unexpected infection of genotype HRV-A21 in the clinic, indicating the necessity of precise genotyping and surveillance of HRVs to improve the clinical management of ARTIs.
has issue date	2017-01-27(xsd:dateTime)
bibo:doi	10.1038/srep41601
bibo:pmid	28128353
has license	cc-by
sha1sum (hex)	59f96c4166966aa929450a859c3d3fb2b6058c50
schema:url	https://doi.org/10.1038/srep41601
resource representing a document's title	Genotyping of human rhinovirus in adult patients with acute respiratory infections identified predominant infections of genotype A21
has PubMed Central identifier	PMC5269714
has PubMed identifier	28128353
schema:publication	Sci Rep
resource representing a document's body	covid:59f96c4166966aa929450a859c3d3fb2b6058c50#body_text
is schema:about of	named entity 'infections' named entity 'suffering' named entity 'antigenic variation' named entity 'patients' covid:arg/59f96c4166966aa929450a859c3d3fb2b6058c50 named entity 'inpatients' named entity 'indicating' named entity 'genotypes' named entity 'neutralized' named entity 'infection' named entity 'patients' named entity 'A21' named entity 'genotyping' named entity 'genome sequenced' named entity 'viral protein' named entity 'HRV' named entity 'A21' named entity 'genotype' named entity 'human rhinovirus' named entity 'acute respiratory infections' named entity 'pathogen' named entity 'airway' named entity 'A21' named entity 'HRV' named entity 'HRV' named entity 'life-threatening' named entity 'HRV' named entity 'IFVs' named entity 'allele' named entity 'hemorrhagic' named entity 'infection' named entity 'metagenomics' named entity 'ATCC' named entity 'microbes' named entity 'HRV' named entity 'Thermo Fisher Scientific' named entity 'A21' named entity 'viruses' named entity 'Enterovirus' named entity 'CAP' named entity 'Genotypes' named entity 'A21' named entity 'COPD' named entity 'gene' named entity 'respiratory symptoms' named entity 'HRV' named entity 'genotypes' named entity 'HRV' named entity 'HRV' named entity 'respiratory illness' named entity 'pathogenesis' named entity 'genotyping' named entity 'cerebrovascular disease' named entity 'tested positive' named entity 'leukopenia' named entity 'CAP' named entity 'HRV' named entity 'GenBank' named entity 'HRV'

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