About: Diagnostic Performance of Chest CT for SARS-CoV-2 Infection in Individuals with or without COVID-19 Symptoms

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About: Diagnostic Performance of Chest CT for SARS-CoV-2 Infection in Individuals with or without COVID-19 Symptoms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Diagnostic Performance of Chest CT for SARS-CoV-2 Infection in Individuals with or without COVID-19 Symptoms
Creator	Bouckaert, Bernard De Smet, Dieter De Smet, Kristof Demedts, Ingel Gryspeerdt, Stefaan Heremans, Birgit Laridon, Emanuel Martens, Geert Ryckaert, Thomas Vandenbulcke, Ruben
source	Medline; PMC
abstract	BACKGROUND: The use of chest CT for COVID-19 diagnosis or triage in healthcare settings with limited SARS-CoV-2 PCR capacity is controversial. CO-RADS categorization of the level of COVID-19 suspicion might improve diagnostic performance. PURPOSE: To investigate the value of chest CT with CO-RADS classification to screen for asymptomatic SARS-CoV-2 infections and to determine its diagnostic performance in individuals with COVID-19 symptoms during the exponential phase of viral spread. MATERIALS AND METHODS: In this secondary analysis of a prospective trial (Clinical Trial Number: IRB B1172020000008), from March 2020 to April 2020, we performed parallel SARS-CoV-2 PCR and CT with categorization of COVID-19 suspicion by CO-RADS, for individuals with COVID-19 symptoms and controls without COVID-19 symptoms admitted to the hospital for medical urgencies unrelated to COVID-19. CT-CORADS was categorized on a 5-point scale from 1 (very low suspicion) to 5 (very high suspicion). AUC were calculated in symptomatic versus asymptomatic individuals to predict positive SARS-CoV-2 positive PCR and likelihood ratios for each CO-RADS score were used for rational selection of diagnostic thresholds. RESULTS: 859 individuals (median 70 years, IQR 52-81, 443 men) with COVID-19 symptoms and 1138 controls (median 68 years, IQR 52-81, 588 men) were evaluated. CT-CORADS had good diagnostic performance (P<.001) in both symptomatic (AUC=.89) and asymptomatic (AUC=.70) individuals. In symptomatic individuals (41.7% PCR+), CO-RADS ≥ 3 detected positive PCR with high sensitivity (89%, 319/358) and 73% specificity. In asymptomatic individuals (5.3% PCR+), a CO-RADS score ≥ 3 detected SARS-CoV-2 infection with low sensitivity (45%, 27/60) but high specificity (89%). CONCLUSION: CT-CORADS had good diagnostic performance in symptomatic individuals, supporting its application for triage. Sensitivity in asymptomatic individuals was insufficient to justify its use as first-line screening approach. Incidental detection of CO-RADS ≥ 3 in asymptomatic individuals should trigger testing for respiratory pathogens.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1148/radiol.2020202708
bibo:pmid	32776832
has license	no-cc
sha1sum (hex)	5a446f033e3ec8724dbe4439eaaeae4b4a7b73a9
schema:url	https://doi.org/10.1148/radiol.2020202708
resource representing a document's title	Diagnostic Performance of Chest CT for SARS-CoV-2 Infection in Individuals with or without COVID-19 Symptoms
has PubMed Central identifier	PMC7418927
has PubMed identifier	32776832
schema:publication	Radiology
resource representing a document's body	covid:5a446f033e3ec8724dbe4439eaaeae4b4a7b73a9#body_text
is schema:about of	named entity 'Symptoms' named entity 'individuals' named entity '95% CI' named entity '8.5' named entity 'probability' named entity '8.5' named entity '7.9' named entity 'COVID' named entity 'chronic lung disease' named entity 'PCR' named entity 'anamnesis' named entity 'MedCalc' named entity 'Seoul' named entity 'triage' named entity 'Fleischner Society' named entity 'eosinophilic pneumonia' named entity 'coronary artery disease' named entity 'COVID' named entity 'American College of Radiology' named entity 'Bronchoalveolar lavage' named entity 'disease prevalence' named entity 'COVID-19' named entity 'lesion' named entity 'Radiology' named entity 'chest CT' named entity 'asymptomatic patients' named entity 'loss of taste' named entity 'nucleated cells' named entity 'COVID' named entity 'infection' named entity 'pediatric' named entity 'post-test probability' named entity 'viruses' named entity 'dyspnea' named entity 'SARS-CoV-2' named entity 'health care' named entity 'disease prevalence' named entity 'control group' named entity 'COVID-19' named entity 'Comorbidities' named entity 'Chi-squared test' named entity 'multi-detector' named entity 'triage' named entity 'pneumonia' named entity 'diffuse alveolar damage' named entity 'chest CT' named entity 'diverticulitis' named entity 'NPV' named entity 'psoriatic arthritis' named entity 'lung' named entity 'PCR' named entity 'chest CT' named entity 'COVID-19' named entity 'COVID' named entity 'study protocol' named entity 'chest CT' named entity 'SARS-CoV-2' named entity 'bronchiectasis' named entity 'dry cough' named entity 'PCR testing' named entity 'SpO2' named entity 'COVID-19' named entity 'supine position' named entity 'chest CT' named entity 'asymptomatic infections' named entity 'ground-glass opacities' named entity 'nasopharyngeal swabs' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'Likelihood ratios' named entity 'pneumonia' named entity 'Thoracic'

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