About: Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus
Creator	Hayashi, Tetsuya Kawada-Matsuo, Miki Komatsuzawa, Hitoshi Nakamura, Norifumi Oogai, Yuichi Oyama, Kentaro
Source	PMC
abstract	Staphylococcus aureus is a major pathogen in humans and causes serious problems due to antibiotic resistance. We investigated the antimicrobial effect of glycyrrhetinic acid (GRA) and its derivatives against 50 clinical S. aureus strains, including 18 methicillin-resistant strains. The minimum inhibitory concentrations (MICs) of GRA, dipotassium glycyrrhizate, disodium succinoyl glycyrrhetinate (GR-SU), stearyl glycyrrhetinate and glycyrrhetinyl stearate were evaluated against various S. aureus strains. Additionally, we investigated the bactericidal effects of GRA and GR-SU against two specific S. aureus strains. DNA microarray analysis was also performed to clarify the mechanism underlying the antibacterial activity of GR-SU. We detected the antimicrobial activities of five agents against S. aureus strains. GRA and GR-SU showed strong antibacterial activities compared to the other three agents tested. At a higher concentration (above 2x MIC), GRA and GR-SU showed bactericidal activity, whereas at a concentration of 1x MIC, they showed a bacteriostatic effect. Additionally, GRA and GR-SU exhibited a synergistic effect with gentamicin. The expression of a large number of genes (including transporters) and metabolic factors (carbohydrates and amino acids) was altered by the addition of GR-SU, suggesting that the inhibition of these metabolic processes may influence the degree of the requirement for carbohydrates or amino acids. In fact, the requirement for carbohydrates or amino acids was increased in the presence of either GRA or GR-SU. GRA and GR-SU exhibited strong antibacterial activity against several S. aureus strains, including MRSA. This activity may be partly due to the inhibition of several pathways involved in carbohydrate and amino acid metabolism.
has issue date	2016-11-07(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0165831
bibo:pmid	27820854
has license	cc-by
sha1sum (hex)	5a4a0f630530c7225fd23178fbdfedd2dccf535c
schema:url	https://doi.org/10.1371/journal.pone.0165831
resource representing a document's title	Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus
has PubMed Central identifier	PMC5098735
has PubMed identifier	27820854
schema:publication	PLoS One
resource representing a document's body	covid:5a4a0f630530c7225fd23178fbdfedd2dccf535c#body_text
is schema:about of	named entity 'activities' named entity 'DNA microarray' named entity 'involved' named entity 'gentamicin' named entity 'transporters' named entity 'stearate' named entity 'activity' named entity 'ANTIBACTERIAL' named entity 'PATHOGEN' named entity 'ALTERED' named entity 'CLINICAL' named entity 'GENES' named entity 'DUE TO' named entity 'ACTIVITY' named entity 'IS A' named entity 'HIGHER' named entity 'MINIMUM' named entity 'ANTIBACTERIAL' named entity 'CONCENTRATIONS' named entity 'DIPOTASSIUM GLYCYRRHIZATE' named entity 'S. AUREUS' named entity 'EITHER' named entity 'TRANSPORTERS' named entity 'STEARATE' named entity 'SPECIFIC' named entity 'STEARYL GLYCYRRHETINATE' named entity 'EFFECT' named entity 'NUMBER OF' named entity 'INCLUDING' named entity 'DNA MICROARRAY ANALYSIS' named entity 'METHICILLIN-RESISTANT' named entity 'DETECTED' named entity 'GRA' named entity 'THESE' named entity 'INCREASED' named entity 'CARBOHYDRATES' named entity 'INFLUENCE' named entity 'ITS' named entity 'A MAJOR' named entity 'CLARIFY' named entity 'GLYCYRRHETINIC ACID' named entity 'BACTERICIDAL ACTIVITY' named entity 'PRESENCE OF' named entity 'ACTIVITIES' named entity 'HUMANS' named entity 'MIC' named entity 'SYNERGISTIC' named entity 'COMPARED' named entity 'INVESTIGATED' named entity 'AMINO ACIDS' named entity 'DEGREE' named entity 'CONCENTRATION OF' named entity 'STAPHYLOCOCCUS AUREUS' named entity 'EFFECTS' named entity 'CARBOHYDRATE' named entity 'GENTAMICIN' named entity 'STRAINS' named entity 'PROBLEMS' named entity 'INHIBITION' named entity 'MECHANISM' named entity 'EXPRESSION' named entity 'UNDERLYING' named entity 'ANTIMICROBIAL' named entity 'AMINO ACID METABOLISM' named entity 'VARIOUS' named entity 'REQUIREMENT' named entity 'MAY BE' named entity 'EVALUATED' named entity 'LARGE' named entity 'CAUSES' named entity 'METABOLIC PROCESSES' named entity 'ADDITION' named entity 'ANTIBIOTIC RESISTANCE' named entity 'INHIBITORY' named entity 'BACTERIOSTATIC EFFECT' named entity 'GLYCYRRHETINATE'

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