About: Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery
Creator	Amoruso, C Holcman, D Lagache, T
Source	ArXiv
abstract	Gene delivery of nucleic acid to the cell nucleus is a fundamental step in gene therapy. In this review of modeling drug and gene delivery, we focus on the particular stage of plasmid DNA or virus cytoplasmic trafficking. A challenging problem is to quantify the success of this limiting stage. We present some models and simulations of plasmid trafficking and of the limiting phase of DNA-polycation escape from an endosome and discuss virus cytoplasmic trafficking. The models can be used to assess the success of viral escape from endosomes, to quantify the early step of viral-cell infection, and to propose new simulation tools for designing new hybrid-viruses as synthetic vectors.
has issue date	2011-09-07(xsd:dateTime)
has license	arxiv
sha1sum (hex)	5a744b0f77de8f967d47aa90c887ce54222050e1
resource representing a document's title	Modeling the early steps of cytoplasmic trafficking in viral infection and gene delivery
resource representing a document's body	covid:5a744b0f77de8f967d47aa90c887ce54222050e1#body_text
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