About: Using the Pathogenic and Nonpathogenic Nonhuman Primate Model for Studying Non-AIDS Comorbidities

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Using the Pathogenic and Nonpathogenic Nonhuman Primate Model for Studying Non-AIDS Comorbidities
Creator	Apetrei, Cristian Pandrea, Ivona Landay, Alan Stock, Jennifer Tracy, Russell Wilson, Cara Apetrei, C Landay, A Pandrea, I Stock, J Tracy, R Wilson, C
Source	PMC
abstract	With the advent of antiretroviral therapy that can control virus replication below the detection levels of conventional assays, a new clinical landscape of AIDS emerged, in which non-AIDS complications prevail over AIDS-defining conditions. These comorbidities are diverse and affect multiple organs, thus resulting in cardiovascular, kidney, neurocognitive and liver disease, osteopenia/osteoporosis, and cancers. A common feature of these conditions is that they are generally associated with accelerated aging. The mechanism behind these comorbidities is chronic excessive inflammation induced by HIV infection, which persists under antiretroviral therapy. Progressive simian immunodeficiency virus (SIV) infection of nonhuman primates (NHPs) closely reproduces these comorbidities and offers a simplified system in which most of the traditional human risk factors for comorbidities (i.e., smoking, hyperlipidemia) are absent. Additionally, experimental conditions can be properly controlled during a shorter course of disease for SIV infection. As such, NHPs can be employed to characterize new paradigms of AIDS pathogenesis and to test the efficacy of interventions aimed at alleviating non-AIDS-related comorbidities.
has issue date	2015-01-22(xsd:dateTime)
bibo:doi	10.1007/s11904-014-0245-5
bibo:pmid	25604236
has license	no-cc
sha1sum (hex)	5a854856c9e4121c95e480efa4c1d6ec87010bcf
schema:url	https://doi.org/10.1007/s11904-014-0245-5
resource representing a document's title	Using the Pathogenic and Nonpathogenic Nonhuman Primate Model for Studying Non-AIDS Comorbidities
has PubMed Central identifier	PMC4369284
has PubMed identifier	25604236
schema:publication	Curr HIV/AIDS Rep
resource representing a document's body	covid:5a854856c9e4121c95e480efa4c1d6ec87010bcf#body_text
is schema:about of	named entity 'simplified' named entity 'affect' named entity 'traditional' named entity 'anti-retroviral therapy' named entity 'absent' named entity 'assays' named entity 'paradigms' named entity 'chronic' named entity 'comorbidities' named entity 'infection' named entity 'employed' named entity 'RESULTING IN' named entity 'TO TEST' named entity 'ABSENT' named entity 'KIDNEY' named entity 'VIRUS REPLICATION' named entity 'CHRONIC' named entity 'INFLAMMATION' named entity 'DETECTION' named entity 'primates' named entity 'conditions' named entity 'system' named entity 'common' named entity 'human' named entity 'detection' named entity 'comorbidities' named entity 'emerged' named entity 'complications' named entity 'comorbidities' named entity 'conditions' named entity 'test' named entity 'pathogenesis' named entity 'comorbidities' named entity 'infection' named entity 'AIDS-related' named entity 'comorbidities' named entity 'anti-retroviral therapy' named entity 'HIV infection' named entity 'comorbidities' named entity 'SIV' named entity 'nonhuman primates' named entity 'AIDS-defining conditions' named entity 'virus replication' named entity 'therapeutic strategies' named entity 'HIV infection' named entity 'CD4' named entity 'hypertension' named entity 'risk factors' named entity 'bronchi' named entity 'life expectancy' named entity 'Hypercoagulation' named entity 'CD4' named entity 'noninfectious' named entity 'histopathological' named entity 'virus' named entity 'kynurenine pathway' named entity 'infection' named entity 'inflammation' named entity 'glomerulopathy' named entity 'CD4' named entity 'macrophage' named entity 'CD4' named entity 'hypertrophy' named entity 'animal model' named entity 'SIV' named entity 'comorbidities' named entity 'CD4' named entity 'SIV' named entity 'HIV' named entity 'monocytes'

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