About: Cuff-Induced Neointimal Formation in Mouse Models

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cuff-Induced Neointimal Formation in Mouse Models
Creator	Kubota, Naoto Kubota, Tetsuya Kubota, N Kubota, T
Source	PMC
abstract	Ischemic heart failure caused by atherosclerosis is a major cause of death worldwide. Although remarkable technological advances have been made in the treatment of coronary heart disease, there is as yet no treatment that can sufficiently suppress the progression of atherosclerosis, including neointimal thickening. Therefore, a precise understanding of the mechanism of neointimal hyperplasia will provide the development of new technologies. Both ApoE-KO and LDLR-KO mice have been employed to generate other relevant mouse models of cardiovascular disease through breeding strategies. Although these mice are effective tools for the investigation of atherosclerosis, development of a progressive atherosclerotic lesion takes a long time, resulting in increase of both the costs and the space needed for the research. Thus, it is necessary to develop simpler tools that would allow easy evaluation of atherosclerosis in mouse models. In this review, we discuss our experience in generating mouse models of cuff-induced injury of the femoral artery and attempt to provide a better understanding of cuff-induced neointimal formation.
has issue date	2015-11-05(xsd:dateTime)
bibo:doi	10.1007/978-4-431-55813-2_2
has license	no-cc
sha1sum (hex)	5a8f3186b70906c2d320f1ed7884af5bf054b229
schema:url	https://doi.org/10.1007/978-4-431-55813-2_2
resource representing a document's title	Cuff-Induced Neointimal Formation in Mouse Models
has PubMed Central identifier	PMC7122099
schema:publication	Mouse Models of Vascular Diseases
resource representing a document's body	covid:5a8f3186b70906c2d320f1ed7884af5bf054b229#body_text
is schema:about of	named entity 'evaluation' named entity 'advances' named entity 'hyperplasia' named entity 'Ischemic' named entity 'EASY' named entity 'atherosclerosis' named entity 'technologies' named entity 'injury' named entity 'long' named entity 'cardiovascular disease' named entity 'provide' named entity 'Formation' named entity 'atherosclerosis' named entity 'KO mice' named entity 'femoral artery' named entity 'ApoE' named entity 'atherosclerosis' named entity 'mouse models' named entity 'mice' named entity 'major' named entity 'IRS1' named entity 'inflammation' named entity 'KO mice' named entity 'ApoE' named entity 'KO mice' named entity 'lipopolysaccharides' named entity 'endothelial cell' named entity 'superoxide' named entity 'receptor' named entity 'CD28' named entity 'dismutation' named entity 'chronic inflammation' named entity 'growth factors' named entity 'neointimal hyperplasia' named entity 'mice' named entity 'immunoglobulin' named entity 'inflammatory cytokines' named entity 'CD28' named entity 'ECM' named entity 'adventitia' named entity 'KO mice' named entity 'immunoreactive' named entity 'adventitial' named entity 'ACE2' named entity 'Tlr2' named entity 'adventitia' named entity 'denudation' named entity 'insulin signaling' named entity '2.1' named entity 'ligation' named entity 'LPS' named entity 'vascular remodeling' named entity 'CD4 +' named entity 'IRS2' named entity 'tissue injury' named entity 'arteries' named entity 'endogenous peptides' named entity 'polyethylene' named entity 'PI3K' named entity 'neointimal hyperplasia' named entity 'subendothelium' named entity 'fat' named entity 'IRS1' named entity 'Rag-1' named entity 'KO mice' named entity 'Macrophages' named entity 'endothelial cells' named entity 'adventitial' named entity 'neointima' named entity 'IgM' named entity 'mice' named entity 'intimal' named entity 'KO mice' named entity 'PDGF' named entity 'neointimal hyperplasia' named entity 'GFP' named entity 'IgG' named entity 'platelets' named entity 'PDGF-BB' named entity 'STAT3'

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