About: Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?
Creator	Taylor, Hugh Feinberg, Eve Glenn, Tanya Katler, Quinton Kawwass, Jennifer Knight, Zac Kotlyar, Alexander Mcqueen, Dana Segars, James Toner, James
source	Elsevier; Medline; PMC
abstract	Structured Abstract Objective To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy. Design Review of English publications in PubMed and Embase to April 6, 2020. Methods Manuscripts were screened for reports including coronavirus, reproduction, including pathophysiology and pregnancy. Intervention(s) None. Main Outcome Measure(s) Reproductive outcomes; effects on gametes; pregnancy outcomes; neonatal complications. Results Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophilins. SARS-CoV-1 may cause severe orchitis leading to germ cell destruction in males. Reports indicate decreased sperm concentration and motility for 72-90 days following COVID-19 infection. Gonadotropin-dependent expression of ACE2 was found in human ovaries, but it is unclear whether SARS-CoV-2 adversely affects female gametogenesis. Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or MERS, but anecdotal reports suggest that infected, asymptomatic women may develop respiratory symptoms postpartum. COVID-19 infections in pregnancy are associated with preterm delivery. Postpartum neonatal transmission from mother to child has been reported. Conclusion COVID-19 infection may adversely affect some pregnant women and their offspring. Additional studies are needed to assess effects of SARS-CoV-2 infection on male and female fertility.
has issue date	2020-04-16(xsd:dateTime)
bibo:doi	10.1016/j.fertnstert.2020.04.025
bibo:pmid	32482250
has license	els-covid
sha1sum (hex)	5ad9816cb2aa221f221d48b96e065c2e5248d983
schema:url	https://doi.org/10.1016/j.fertnstert.2020.04.025
resource representing a document's title	Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?
has PubMed Central identifier	PMC7161522
has PubMed identifier	32482250
schema:publication	Fertil Steril
resource representing a document's body	covid:5ad9816cb2aa221f221d48b96e065c2e5248d983#body_text
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