About: Another triple-spanning envelope protein among intracellularly budding RNA viruses: The torovirus E protein

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About: Another triple-spanning envelope protein among intracellularly budding RNA viruses: The torovirus E protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Another triple-spanning envelope protein among intracellularly budding RNA viruses: The torovirus E protein
Creator	Horzinek, Marian Den Boon,', Johan Locker, Krijnse Rot-Tier2, Peter Snijder,' Jacomine, Eric
Source	Elsevier; Medline; PMC
abstract	Abstract The nucleotide sequence of the Berne virus envelope (E) protein gene was determined and its 26.5K translation product was identified by in vitro transcription and translation. Computer analysis of the protein sequence revealed the characteristics of a class III membrane protein lacking a cleaved signal sequence but containing three successive transmembrane α-helices in the N-terminal half, much the same as the coronavirus membrane (M) protein. The disposition of the E protein in the membrane was studied by in vitro translation in the presence of microsomes and by subsequent proteinase K digestion. Only small portions of either end of the polypeptide were found to be exposed on opposite sides of the vesicle membranes. Experiments with a hybrid E protein (EM) containing the C-terminal tail of a coronavirus M protein, to which an anti-peptide serum was available, showed that this C-terminus was present at the cytoplasmic side of the membrane, which is another similarity to the coronavirus M protein. Immunofluorescence experiments indicated that the EM protein, expressed by a recombinant vaccinia virus, accumulated in intracellular membranes, predominantly those of the endoplasmic reticulum. The common features of the torovirus E and the coronavirus M protein support our hypothesis that an evolutionary relationship exists between these groups of intracellularly budding viruses.
has issue date	1991-06-30(xsd:dateTime)
bibo:doi	10.1016/0042-6822(91)90606-c
bibo:pmid	2024492
has license	els-covid
sha1sum (hex)	5b0e01ca31343bc3450b28109c522b2b23cbd5b6
schema:url	https://doi.org/10.1016/0042-6822%2891%2990606-c
resource representing a document's title	Another triple-spanning envelope protein among intracellularly budding RNA viruses: The torovirus E protein
has PubMed Central identifier	PMC7130535
has PubMed identifier	2024492
schema:publication	Virology
resource representing a document's body	covid:5b0e01ca31343bc3450b28109c522b2b23cbd5b6#body_text
is schema:about of	named entity 'determined' named entity 'disposition' named entity 'vesicle' named entity 'successive' named entity 'sequence' named entity 'gene' named entity 'Envelope' named entity 'Budding' named entity 'BUDDING' named entity 'PRESENCE OF' named entity 'PROTEIN GENE' named entity 'OPPOSITE' named entity 'ACADEMIC' named entity 'ITS' named entity 'SERUM' named entity 'AVAILABLE' named entity 'FEATURES' named entity 'RNA VIRUSES' covid:arg/5b0e01ca31343bc3450b28109c522b2b23cbd5b6 named entity 'ENVELOPE PROTEIN' named entity 'EXPERIMENTS' named entity 'RELATIONSHIP' named entity 'IN VITRO TRANSLATION' named entity 'EXPOSED' named entity 'BUDDING' named entity 'TOROVIRUS' named entity 'TRIPLE' named entity 'PROTEIN ' named entity 'PROTEINASE K DIGESTION' named entity 'CYTOPLASMIC' named entity 'ENDOPLASMIC RETICULUM' named entity 'HYPOTHESIS' named entity 'MUCH' named entity 'NUCLEOTIDE SEQUENCE' named entity 'GROUPS' named entity 'PEPTIDE' named entity 'MEMBRANE' named entity 'TRANSMEMBRANE' named entity 'VIRUSES' named entity 'CHARACTERISTICS' named entity 'CORONAVIRUS' named entity 'EITHER' named entity 'IN VITRO TRANSCRIPTION' named entity 'SUPPORT' named entity 'THESE' named entity 'E PROTEIN' named entity 'LACKING' named entity 'E PROTEIN' named entity 'SIMILARITY' named entity 'VESICLE' named entity 'END' named entity 'INTRACELLULAR MEMBRANES' named entity 'SUCCESSIVE' named entity 'COMMON' named entity 'OUR' named entity 'SIGNAL SEQUENCE' named entity 'DETERMINED' named entity 'TRANSLATION' named entity 'N-TERMINAL ' named entity 'PROTEIN ' named entity 'HYBRID' named entity 'TAIL' named entity 'CONTAINING' named entity 'PROTEIN SEQUENCE' named entity 'PRESENT' named entity 'FOUND' named entity 'COMPUTER ANALYSIS' named entity 'POLYPEPTIDE' named entity 'C-TERMINAL' named entity 'C-TERMINUS' named entity 'BERNE VIRUS' named entity 'HALF' named entity 'HELICES' named entity 'PROTEIN' named entity 'ILL' named entity 'REVEALED' named entity 'TOROVIRUS'

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