About: The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins

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About: The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins
Creator	Uversky, Vladimir
Source	Medline; PMC
abstract	The ability of a protein to fold into unique functional state or to stay intrinsically disordered is encoded in its amino acid sequence. Both ordered and intrinsically disordered proteins (IDPs) are natural polypeptides that use the same arsenal of 20 proteinogenic amino acid residues as their major building blocks. The exceptional structural plasticity of IDPs, their capability to exist as heterogeneous structural ensembles and their wide array of important disorder-based biological functions that complements functional repertoire of ordered proteins are all rooted within the peculiar differential usage of these building blocks by ordered proteins and IDPs. In fact, some residues (so-called disorder-promoting residues) are noticeably more common in IDPs than in sequences of ordered proteins, which, in their turn, are enriched in several order-promoting residues. Furthermore, residues can be arranged according to their “disorder promoting potencies,” which are evaluated based on the relative abundances of various amino acids in ordered and disordered proteins. This review continues a series of publications on the roles of different amino acids in defining the phenomenon of protein intrinsic disorder and concerns glutamic acid, which is the second most disorder-promoting residue.
has issue date	2013-04-01(xsd:dateTime)
bibo:doi	10.4161/idp.24684
bibo:pmid	28516010
has license	cc-by-nc
sha1sum (hex)	5b0eeabeded14c9e02fc7bcfacb52a8fa0b3ae3c
schema:url	https://doi.org/10.4161/idp.24684
resource representing a document's title	The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins
has PubMed Central identifier	PMC5424795
has PubMed identifier	28516010
schema:publication	Intrinsically Disord Proteins
resource representing a document's body	covid:5b0eeabeded14c9e02fc7bcfacb52a8fa0b3ae3c#body_text
is schema:about of	named entity 'ROLES' named entity 'RESIDUE' named entity 'DISORDERED' named entity 'PROMOTING' named entity 'DEFINING' named entity 'POLYPEPTIDES' named entity 'A PROTEIN' named entity 'GLUTAMIC ACID' named entity 'VARIOUS' named entity 'CONCERNS' named entity 'PHENOMENON' named entity 'ITS' named entity 'USAGE' named entity 'INTRINSIC DISORDER' named entity 'PROTEINOGENIC AMINO ACID RESIDUES' named entity 'FUNCTIONAL' named entity 'PLASTICITY' named entity 'MAJOR' named entity 'UNIQUE' named entity 'PROTEIN ' named entity 'ENCODED' named entity 'RELATIVE' named entity 'proteins' named entity 'IDPs' named entity 'phenomenon' named entity 'DIFFERENT' named entity 'IMPORTANT' named entity 'THESE' named entity 'COMMON' named entity 'STRUCTURAL' named entity 'FACT' named entity 'REVIEW' named entity 'SEQUENCES' named entity 'ROOTED' named entity 'INTRINSICALLY DISORDERED PROTEINS' named entity 'ACCORDING' named entity 'ORDERED' named entity 'EXIST' named entity 'INTRINSICALLY DISORDERED PROTEINS' named entity 'ABILITY' named entity 'USE' named entity 'EVALUATED' named entity 'BASED' named entity 'PROTEINS' named entity 'NATURAL' named entity 'FUNCTIONAL STATE' named entity 'ARRAY' named entity 'PECULIAR' named entity 'BUILDING' named entity 'BIOLOGICAL FUNCTIONS' named entity 'HETEROGENEOUS' named entity 'WIDE' named entity 'ENRICHED' named entity 'THEIR' named entity 'FOLD' named entity 'SECOND' named entity 'REPERTOIRE' named entity 'AMINO ACID SEQUENCE' named entity 'COMPLEMENTS' named entity 'DISORDER' named entity 'AMINO ACIDS' named entity 'ARSENAL' named entity 'DIFFERENTIAL' named entity 'CAPABILITY' named entity 'BLOCKS' named entity 'TURN' named entity 'SERIES' named entity 'PUBLICATIONS' named entity 'disordered' named entity 'polypeptides' named entity 'continues' named entity 'encoded' named entity 'unique' named entity 'blocks' named entity 'proteins' named entity 'arsenal' named entity 'functional' named entity 'residues' named entity 'wide array' named entity 'glutamic acid' named entity 'intrinsically disordered'

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