About: Chemical microarray: a new tool for drug screening and discovery

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chemical microarray: a new tool for drug screening and discovery
Creator	Ma, Haiching Horiuchi, Kurumi
Source	Elsevier; Medline; PMC
abstract	HTS with microtiter plates has been the major tool used in the pharmaceutical industry to explore chemical diversity space and to identify active compounds and pharmacophores for specific biological targets. However, HTS faces a daunting challenge regarding the fast-growing numbers of drug targets arising from genomic and proteomic research, and large chemical libraries generated from high-throughput synthesis. There is an urgent need to find new ways to profile the activity of large numbers of chemicals against hundreds of biological targets in a fast, low-cost fashion. Chemical microarray can rise to this challenge because it has the capability of identifying and evaluating small molecules as potential therapeutic reagents. During the past few years, chemical microarray technology, with different surface chemistries and activation strategies, has generated many successes in the evaluation of chemical–protein interactions, enzyme activity inhibition, target identification, signal pathway elucidation and cell-based functional analysis. The success of chemical microarray technology will provide unprecedented possibilities and capabilities for parallel functional analysis of tremendous amounts of chemical compounds.
has issue date	2006-07-01(xsd:dateTime)
bibo:doi	10.1016/j.drudis.2006.05.002
bibo:pmid	16793536
has license	green-oa
sha1sum (hex)	5b33d93a5e943df43ae875998b4431cdf573bea2
schema:url	https://doi.org/10.1016/j.drudis.2006.05.002
resource representing a document's title	Chemical microarray: a new tool for drug screening and discovery
has PubMed Central identifier	PMC2577215
has PubMed identifier	16793536
schema:publication	Drug Discovery Today
resource representing a document's body	covid:5b33d93a5e943df43ae875998b4431cdf573bea2#body_text
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