About: Household transmission of SARS-CoV-2: a systematic review and meta-analysis of secondary attack rate

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About: Household transmission of SARS-CoV-2: a systematic review and meta-analysis of secondary attack rate Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Household transmission of SARS-CoV-2: a systematic review and meta-analysis of secondary attack rate
Creator	Yang, Yang Halloran, M Longini, Ira Dean, Natalie Madewell, Zachary
source	MedRxiv; Medline; PMC
abstract	BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spread by direct, indirect, or close contact with infected people via infected respiratory droplets or saliva. Crowded indoor environments with sustained close contact and conversations are a particularly high-risk setting. METHODS: We performed a meta-analysis through July 29, 2020 of SARS-CoV-2 household secondary attack rate (SAR), disaggregating by several covariates (contact type, symptom status, adult/child contacts, contact sex, relationship to index case, index case sex, number of contacts in household, coronavirus). FINDINGS: We identified 40 relevant published studies that report household secondary transmission. The estimated overall household SAR was 18·8% (95% confidence interval [CI]: 15·4%–22·2%), which is higher than previously observed SARs for SARS-CoV and MERS-CoV. We observed that household SARs were significantly higher from symptomatic index cases than asymptomatic index cases, to adult contacts than children contacts, to spouses than other family contacts, and in households with one contact than households with three or more contacts. INTERPRETATION: To prevent the spread of SARS-CoV-2, people are being asked to stay at home worldwide. With suspected or confirmed infections referred to isolate at home, household transmission will continue to be a significant source of transmission.
has issue date	2020-07-31(xsd:dateTime)
bibo:doi	10.1101/2020.07.29.20164590
bibo:pmid	32766596
has license	cc-by-nc-nd
sha1sum (hex)	5b496c74c01f9c006ba209eba148660334a8868b
schema:url	https://doi.org/10.1101/2020.07.29.20164590
resource representing a document's title	Household transmission of SARS-CoV-2: a systematic review and meta-analysis of secondary attack rate
has PubMed Central identifier	PMC7402051
has PubMed identifier	32766596
schema:publication	medRxiv
resource representing a document's body	covid:5b496c74c01f9c006ba209eba148660334a8868b#body_text
is schema:about of	named entity 'systematic review' named entity 'DIRECT' covid:arg/5b496c74c01f9c006ba209eba148660334a8868b named entity 'close' named entity 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'respiratory droplets' named entity 'SARS-CoV-2' named entity 'Severe acute respiratory syndrome coronavirus 2' named entity 'attack rate' named entity 'meta-analysis' named entity 'systematic review' named entity 'sustained' named entity 'respiratory droplets' named entity 'saliva' named entity 'ENVIRONMENTS' named entity 'SPREAD' named entity 'SUSTAINED' named entity 'BACKGROUND' named entity 'RESPIRATORY' named entity 'CLOSE CONTACT' named entity 'SALIVA' named entity 'high-risk' named entity 'SARS-CoV-2' named entity 'HIGH-RISK' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2' named entity 'INDOOR' named entity 'saliva' named entity 'close' named entity 'contact' named entity 'conversations' named entity 'infected' named entity 'PEOPLE' named entity 'Crowded' named entity 'contact' named entity 'infected' named entity 'SARS-CoV-2' named entity 'Household' named entity 'transmission' named entity 'INFECTED' named entity 'meta-analysis' named entity 'attack rate' named entity 'INDIRECT' named entity 'SETTING' named entity 'CONTACT WITH' named entity 'CONVERSATIONS' named entity 'CROWDED' named entity 'META-ANALYSIS' named entity 'SARS-COV-2' named entity 'SECONDARY' named entity 'ATTACK RATE' named entity 'HOUSEHOLD' named entity 'SYSTEMATIC REVIEW' named entity 'TRANSMISSION' nodeID://b56999570 nodeID://b56999622 nodeID://b57007350 nodeID://b57033994 nodeID://b57081978 nodeID://b57204566 nodeID://b57261866 nodeID://b57375398 nodeID://b57375422 nodeID://b57421034 nodeID://b57467602 nodeID://b57521338 nodeID://b57614994 nodeID://b57704502 nodeID://b57927086
is wasQuotedFrom of	covid:arg/5b496c74c01f9c006ba209eba148660334a8868b/1 covid:arg/5b496c74c01f9c006ba209eba148660334a8868b/0
is part of of	covid:5b496c74c01f9c006ba209eba148660334a8868b#body_text BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spread by direct, indirect, or close contact with infected people via infected respiratory droplets or saliva. Crowded indoor environments with sustained close contact and conversations are a particularly high-risk setting. METHODS: We performed a meta-analysis through July 29, 2020 of SARS-CoV-2 household secondary attack rate (SAR), disaggregating by several covariates (contact type, symptom status, adult/child contacts, contact sex, relationship to index case, index case sex, number of contacts in household, coronavirus). FINDINGS: We identified 40 relevant published studies that report household secondary transmission. The estimated overall household SAR was 18·8% (95% confidence interval [CI]: 15·4%–22·2%), which is higher than previously observed SARs for SARS-CoV and MERS-CoV. We observed that household SARs were significantly higher from symptomatic index cases than asymptomatic index cases, to adult contacts than children contacts, to spouses than other family contacts, and in households with one contact than households with three or more contacts. INTERPRETATION: To prevent the spread of SARS-CoV-2, people are being asked to stay at home worldwide. With suspected or confirmed infections referred to isolate at home, household transmission will continue to be a significant source of transmission. Household transmission of SARS-CoV-2: a systematic review and meta-analysis of secondary attack rate

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