About: Magnetically enhanced nucleic acid delivery. Ten years of magnetofection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects
Creator	Mykhaylyk, Olga Plank, Christian Zelphati, Olivier
Source	Elsevier; Medline; PMC
abstract	Abstract Nucleic acids carry the building plans of living systems. As such, they can be exploited to make cells produce a desired protein, or to shut down the expression of endogenous genes or even to repair defective genes. Hence, nucleic acids are unique substances for research and therapy. To exploit their potential, they need to be delivered into cells which can be a challenging task in many respects. During the last decade, nanomagnetic methods for delivering and targeting nucleic acids have been developed, methods which are often referred to as magnetofection. In this review we summarize the progress and achievements in this field of research. We discuss magnetic formulations of vectors for nucleic acid delivery and their characterization, mechanisms of magnetofection, and the application of magnetofection in viral and nonviral nucleic acid delivery in cell culture and in animal models. We summarize results that have been obtained with using magnetofection in basic research and in preclinical animal models. Finally, we describe some of our recent work and end with some conclusions and perspectives.
has issue date	2011-11-30(xsd:dateTime)
bibo:doi	10.1016/j.addr.2011.08.002
bibo:pmid	21893135
has license	els-covid
sha1sum (hex)	5b61183e326bb556ea31f49b764de2b1f95ad3b8
schema:url	https://doi.org/10.1016/j.addr.2011.08.002
resource representing a document's title	Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects
has PubMed Central identifier	PMC7103316
has PubMed identifier	21893135
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:5b61183e326bb556ea31f49b764de2b1f95ad3b8#body_text
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