About: The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2
Creator	Farzan, Michael Huang, I-Chueh Choe, Hyeryun Li, Wenhui Sui, Jianhua Kuhn, Jens Marasco, Wayne Radoshitzky, Sheli
Source	Elsevier; Medline; PMC
abstract	The cellular receptor for human coronavirus NL63 (HCoV-NL63), a group I coronavirus, is angiotensin-converting enzyme2 (ACE2). ACE2 is also the receptor for the SARS coronavirus (SARS-CoV), a group II coronavirus. Here we describe the ability of HCoV-NL63 to utilize a number of ACE2 variants previously characterized as SARS-CoV receptors. Several ACE2 variants that reduced SARS-CoV S-protein association similarly reduced that of HCoV-NL63, whereas alteration of a number of solvent-exposed ACE2 residues did not interfere with binding by either S protein. One notable exception is ACE2 residue 354, at the boundary of the SARS-CoV binding site, whose alteration markedly inhibited utilization by the HCoV-NL63 but not SARS-CoV S proteins. In addition, the SARS-CoV S-protein receptor-binding domain inhibited entry mediated by the HCoV-NL63 S protein. These studies indicate that HCoV-NL63, like SARS-CoV, associates region of human ACE2 that includes a key loop formed by β-strands 4 and 5.
has issue date	2007-10-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2007.04.035
bibo:pmid	17631932
has license	bronze-oa
sha1sum (hex)	5b6d0627edda9c01407369dc58f008d8facd987a
schema:url	https://doi.org/10.1016/j.virol.2007.04.035
resource representing a document's title	The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2
has PubMed Central identifier	PMC2693060
has PubMed identifier	17631932
schema:publication	Virology
resource representing a document's body	covid:5b6d0627edda9c01407369dc58f008d8facd987a#body_text
is schema:about of	named entity 'OVERLAPPING' named entity 'HUMAN CORONAVIRUS NL63' named entity 'NUMBER OF' named entity 'ACE2' named entity 'DID NOT INTERFERE WITH' named entity 'RECEPTORS' named entity 'EITHER' named entity 'DESCRIBE' named entity 'ALTERATION' named entity 'CORONAVIRUS' named entity 'VARIANTS' named entity 'REDUCED' named entity 'CELLULAR' named entity 'SARS CORONAVIRUS' named entity 'BIND' named entity 'PROTEINS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ACE2' named entity 'REGIONS' named entity 'ABILITY' named entity 'PREVIOUSLY' named entity 'SOLVENT' named entity 'HUMAN CORONAVIRUS NL63' named entity 'S-PROTEIN' named entity 'A GROUP' named entity 'ASSOCIATION' named entity 'PROTEIN ' named entity 'RECEPTOR' named entity 'S PROTEIN' named entity 'BINDING' named entity 'GROUP I' named entity 'CHARACTERIZED' named entity 'NL63' named entity 'CONVERTING' named entity 'GROUP II' named entity 'ANGIOTENSIN' named entity 'SARS-COV' named entity 'EXPOSED' named entity 'HERE' covid:arg/5b6d0627edda9c01407369dc58f008d8facd987a named entity 'binding' named entity 'mutagenesis' named entity 'tyrosine' named entity 'ACE2' named entity 'convergent evolution' named entity 'ACE2' named entity 'protein' named entity 'antibody' named entity 'ACE2' named entity 'PBS' named entity 'RBD' named entity 'PCR' named entity 'PubMed Central' named entity 'SARS-CoV' named entity 'binding sites' named entity 'RBD' named entity 'viruses' named entity 'ACE2' named entity 'HCoV-NL63' named entity 'binding motif' named entity 'HCoV-NL63' named entity 'SARS-CoV' named entity 'ACE2' named entity 'entry inhibitors' named entity 'SARS-CoV' named entity 'infection' named entity 'amino-terminal' named entity 'ACE2' named entity 'ACE2' named entity 'glycosylated' named entity 'ACE2' named entity 'Luminometer' named entity 'RBD' named entity 'ACE2'

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