About: Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update

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About: Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update
Creator	Porter, Christopher Charman, William Trevaskis, Natalie
source	Elsevier; Medline; PMC
abstract	Abstract After oral administration, the majority of drug molecules are absorbed across the small intestine and enter the systemic circulation via the portal vein and the liver. For some highly lipophilic drugs (typically log P >5, lipid solubility>50 mg/g), however, association with lymph lipoproteins in the enterocyte leads to transport to the systemic circulation via the intestinal lymph. The attendant delivery benefits associated with lymphatic drug transport include a reduction in first-pass metabolism and lymphatic exposure to drug concentrations orders of magnitude higher than that attained in systemic blood. In the current review we briefly describe the mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport. Specific focus is directed toward recent advances in understanding regarding the impact of lipid source (both endogenous and exogenous) and intracellular lipid trafficking pathways on lymphatic drug transport and enterocyte-based first-pass metabolism.
has issue date	2008-03-17(xsd:dateTime)
bibo:doi	10.1016/j.addr.2007.09.007
bibo:pmid	18155316
has license	els-covid
sha1sum (hex)	5ba58a520dc03bfa79f4d2195e418e446746156b
schema:url	https://doi.org/10.1016/j.addr.2007.09.007
resource representing a document's title	Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update
has PubMed Central identifier	PMC7103284
has PubMed identifier	18155316
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:5ba58a520dc03bfa79f4d2195e418e446746156b#body_text
is schema:about of	named entity 'BASED' named entity 'transport' named entity 'drug' named entity 'transport' named entity 'drug' named entity 'transport' named entity 'leads' named entity 'higher' named entity 'strategies' named entity 'INTESTINAL' named entity 'ENDOGENOUS' named entity 'LIPOPROTEINS' named entity 'MECHANISMS' named entity 'REDUCTION' named entity 'TO TRANSPORT' named entity 'INTRACELLULAR' named entity 'STRATEGIES' named entity 'ENTEROCYTE' named entity 'SOURCE' named entity 'LEADS' named entity 'DELIVERY' named entity 'ATTENDANT' named entity 'DRUGS' named entity 'DRUG TRANSPORT' named entity 'ASSOCIATED WITH' named entity 'HIGHLY' named entity 'SYSTEMIC' named entity 'LYMPH' named entity 'SPECIFIC' named entity 'FORMULATION' named entity 'SYSTEMIC CIRCULATION' named entity 'ENTER' named entity 'MG%' named entity 'ASSOCIATION' named entity 'CONCENTRATIONS' named entity 'MOLECULES' named entity 'MAY BE' named entity 'LYMPHATIC' named entity 'BLOOD' named entity 'ENHANCE' named entity 'FOCUS' named entity 'LIPID' named entity 'LIPID TRAFFICKING' named entity 'DESCRIBE' named entity 'UPDATE' named entity 'DRUG TRANSPORT' named entity 'PASS' named entity 'ACROSS' named entity 'EXOGENOUS' named entity 'ORAL ADMINISTRATION' named entity 'LIVER' named entity 'DRUG' named entity 'BASED' named entity 'IMPACT' named entity 'SMALL INTESTINE' named entity 'DIRECTED' named entity 'RECENT' named entity 'ORDERS' named entity 'UNDERSTANDING' named entity 'INTESTINAL' named entity 'PATHWAYS' named entity 'LIPID' named entity 'ACCESS' named entity 'DELIVERY SYSTEMS' named entity 'LYMPHATIC' named entity 'MAGNITUDE' named entity 'PORTAL VEIN' named entity 'LIPID SOLUBILITY' named entity 'BENEFITS' named entity 'INCLUDE' named entity 'CURRENT REVIEW' named entity 'MAJORITY' named entity 'LIPOPHILIC' named entity 'LOG' named entity 'majority' named entity 'concentrations' named entity 'drug' named entity 'focus' named entity 'first-pass metabolism'

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