About: A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles
Creator	De Menna, Marta Gray, Peter Karkampouna, Sofia Rodrigues Sousa, Elisa Zoni, Eugenio Kruithof-De Julio, Marianna Manna, Federico
Source	PMC
abstract	Cripto is a small glycosylphosphatidylinisitol (GPI)-anchored and secreted oncofetal protein that plays important roles in regulating normal physiological processes, including stem cell differentiation, embryonal development, and tissue growth and remodeling, as well as pathological processes such as tumor initiation and progression. Cripto functions as a co-receptor for TGF-β ligands such as Nodal, GDF1, and GDF3. Soluble and secreted forms of Cripto also exhibit growth factor-like activity and activate SRC/MAPK/PI3K/AKT pathways. Glucose-Regulated Protein 78 kDa (GRP78) binds Cripto at the cell surface and has been shown to be required for Cripto signaling via both TGF-β and SRC/MAPK/PI3K/AKT pathways. To provide a comprehensive overview of the scientific literature related to Cripto, we performed, for the first time, a bibliometric analysis of the biological roles of Cripto as reported in the scientific literature covering the last 10 years. We present different fields of knowledge in comprehensive areas of research on Cripto, ranging from basic to translational research, using a keyword-driven approach. Our ultimate aim is to aid the scientific community in conducting targeted research by identifying areas where research has been conducted so far and, perhaps more importantly, where critical knowledge is still missing.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.3390/cancers12061480
bibo:pmid	32517087
has license	cc-by
sha1sum (hex)	5bd4f9f4e34a62bbf5475399a3bd498d9ba0cd7d
schema:url	https://doi.org/10.3390/cancers12061480
resource representing a document's title	A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles
has PubMed Central identifier	PMC7352664
has PubMed identifier	32517087
schema:publication	Cancers (Basel)
resource representing a document's body	covid:5bd4f9f4e34a62bbf5475399a3bd498d9ba0cd7d#body_text
is schema:about of	named entity 'regulating' named entity 'ranging' named entity 'additional' named entity 'partially' named entity 'secreted' named entity 'tumorigenesis' named entity 'PI3K' named entity 'tissue' named entity 'protein' named entity 'Soluble' named entity 'AKT' named entity 'activity' named entity 'progression' named entity 'MAPK' named entity 'Review' named entity 'Multidisciplinary' named entity 'IS A' named entity 'PRESENT' named entity 'NORMAL TISSUE' named entity 'GLUCOSE-REGULATED PROTEIN 78' named entity 'ACTIVATE' named entity 'homeostasis' named entity 'signaling pathways' named entity 'TGF-β' named entity 'regulate' named entity 'signaling' named entity 'surface' named entity 'functions' named entity 'biological' named entity 'critical' named entity 'interaction' named entity 'bibliometric' named entity 'binds' named entity 'anchored' named entity 'SRC' named entity 'However' named entity 'Therefore' named entity 'remain' named entity 'conducting' named entity 'tissue growth' named entity 'PI3K/AKT' named entity 'stem cell differentiation' named entity 'SRC' named entity 'PI3K/AKT' named entity 'molecular mechanisms' named entity 'Cripto' named entity 'tissue homeostasis' named entity 'Cripto' named entity 'biological roles' named entity 'ligands' named entity 'GDF3' named entity 'protein' named entity 'Multidisciplinary' named entity 'comprehensive' named entity 'factorial' named entity 'GRP78' named entity 'ligand' named entity 'primitive endoderm' named entity 'human tissues' named entity 'antibodies' named entity 'xenograft' named entity 'Nodal' named entity 'breast cancer' named entity 'protein' named entity 'bibliometric analysis' named entity 'Cripto' named entity 'Cripto' named entity 'phosphorylated' named entity 'Cripto' named entity 'Nodal' named entity 'Cripto' named entity 'CRIPTO' named entity 'miR' named entity 'epiblast' named entity 'Saracatinib'

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