About: CNS viral infection diverts homing of antibody‐secreting cells from lymphoid organs to the CNS

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	CNS viral infection diverts homing of antibody‐secreting cells from lymphoid organs to the CNS
Creator	Atkinson, Roscoe Ramakrishna, Chandran Bergmann, Cornelia Hinton, David Stohlman, Stephen Tschen, Shuen-Ing
source	Medline; PMC
abstract	Neurotropic coronavirus infection of mice results in acute encephalomyelitis followed by viral persistence. Whereas cellular immunity controls acute infection, humoral immunity regulates central nervous system (CNS) persistence. Maintenance of serum Ab was correlated with tissue distribution of virus‐specific Ab‐secreting cells (ASC). Although virus‐specific ASC declined in cervical lymph node and spleen after infectious virus clearance, virus‐specific serum Ab was sustained at steady levels, with a delay in neutralizing Ab. Virus‐specific ASC within the CNS peaked rapidly 1 wk after control of infectious virus and were retained throughout chronic infection, consistent with intrathecal Ab synthesis. Surprisingly, frequencies of ASC in the BM remained low and only increased gradually. Nevertheless, virus‐specific ASC induced by peripheral infection localized to both spleen and BM. The data suggest that CNS infection provides strong stimuli to recruit ASC into the inflamed tissue through sustained up‐regulation of the CXCR3 ligands CXCL9 and CXCL10. Irrespective of Ag deprivation, CNS retention of ASC coincided with elevated BAFF expression and ongoing differentiation of class II(+ )to class II(–)CD138(+)CD19(+ )plasmablasts. These results confirm the CNS as a major ASC‐supporting environment, even after resolution of viral infection and in the absence of chronic ongoing inflammation.
has issue date	2006-01-25(xsd:dateTime)
bibo:doi	10.1002/eji.200535123
bibo:pmid	16437540
has license	no-cc
sha1sum (hex)	5bd9a8cbba75c8ee241ee3870d02dbe437b6f60f
schema:url	https://doi.org/10.1002/eji.200535123
resource representing a document's title	CNS viral infection diverts homing of antibody‐secreting cells from lymphoid organs to the CNS
has PubMed Central identifier	PMC7163565
has PubMed identifier	16437540
schema:publication	Eur J Immunol
resource representing a document's body	covid:5bd9a8cbba75c8ee241ee3870d02dbe437b6f60f#body_text
is schema:about of	named entity 'tissue' named entity 'data' named entity 'CXCL10' named entity 'chronic infection' named entity 'ASC' named entity 'retention' named entity 'serum' named entity 'inflammation' named entity 'homing' named entity 'TISSUE DISTRIBUTION' named entity 'LOW' named entity 'BAFF' named entity 'virus-specific' named entity 'environment' named entity 'cells' named entity 'ASC' named entity 'stimuli' named entity 'localized' named entity 'plasmablasts' named entity 'induced' named entity 'CD138' named entity 'CXCL9' named entity 'declined' named entity 'spleen' named entity 'differentiation' named entity 'control' named entity 'levels' named entity 'CNS' named entity 'viral infection' named entity 'infection' named entity 'CD19' named entity 'CXCL9' named entity 'Virus' named entity 'inflammation' named entity 'virus' named entity 'acute infection' named entity 'Neurotropic' named entity 'class II' named entity 'CXCR3' named entity 'CNS' named entity 'CNS' named entity 'CNS' named entity 'chronic inflammation' named entity 'germinal centers' named entity 'IgG' named entity 'activated B cells' named entity 'humoral immunity' named entity 'CNS' named entity 'BALB' named entity 'goat' named entity 'CNS' named entity 'intrathecal' named entity 'viral infection' named entity 'intrathecal' named entity 'IgG' named entity 'serum' named entity 'serum' named entity 'viral replication' named entity 'plasmablast' named entity 'BAFF' named entity 'CXCL9' named entity 'serum' named entity 'intrathecal' named entity 'CNS' named entity 'CNS' named entity 'phenotype' named entity 'CNS' named entity 'clonal' named entity 'molecule' named entity 'spleen' named entity 'mRNA' named entity 'IgM' named entity 'spinal cords' named entity 'CXCL9' named entity 'IgG' named entity 'CNS'

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