About: SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection

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About: SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection
Creator	Abraham, Thomas Silveyra, Patricia Wang, Hong Takahashi, Yoshinori Chroneos, Zissis Diangelo, Susan Umstead, Todd Cooper, Timothy Fino, Kristin Halstead, E Hu, Sanmei Yang, Linlin Zhou, Zhixiang
Source	PMC
abstract	New influenza A viruses that emerge frequently elicit composite inflammatory responses to both infection and structural damage of alveolar-capillary barrier cells that hinders regeneration of respiratory function. The host factors that relinquish restoration of lung health to enduring lung injury are insufficiently understood. Here, we investigated the role of endophilin B2 (B2) in susceptibility to severe influenza infection. WT and B2-deficient mice were infected with H1N1 PR8 by intranasal administration and course of influenza pneumonia, inflammatory, and tissue responses were monitored over time. Disruption of B2 enhanced recovery from severe influenza infection as indicated by swift body weight recovery and significantly better survival of endophilin B2-deficient mice compared to WT mice. Compared to WT mice, the B2-deficient lungs exhibited induction of genes that express surfactant proteins, ABCA3, GM-CSF, podoplanin, and caveolin mRNA after 7 days, temporal induction of CCAAT/enhancer binding protein CEBPα, β, and δ mRNAs 3–14 days after infection, and differences in alveolar extracellular matrix integrity and respiratory mechanics. Flow cytometry and gene expression studies demonstrated robust recovery of alveolar macrophages and recruitment of CD4+ lymphocytes in B2-deficient lungs. Targeting of endophilin B2 alleviates adverse effects of IAV infection on respiratory and immune cells enabling restoration of alveolar homeostasis.
has issue date	2017-08-04(xsd:dateTime)
bibo:doi	10.1038/s41598-017-07724-5
bibo:pmid	28779131
has license	cc-by
sha1sum (hex)	5bf02358441fc02afdfac662be366dd775c02a7b
schema:url	https://doi.org/10.1038/s41598-017-07724-5
resource representing a document's title	SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection
has PubMed Central identifier	PMC5544693
has PubMed identifier	28779131
schema:publication	Sci Rep
resource representing a document's body	covid:5bf02358441fc02afdfac662be366dd775c02a7b#body_text
is schema:about of	named entity 'intranasal administration' named entity 'influenza' named entity 'severe' named entity 'influenza' named entity 'mRNA' named entity 'lungs' named entity 'macrophages' named entity 'studies' named entity 'severe' named entity 'SURFACTANT' named entity 'HOST' named entity 'LUNGS' named entity 'UNDERSTOOD' named entity 'RELINQUISH' named entity 'TISSUE' named entity 'COMPARED' named entity 'ALVEOLAR' named entity 'infection' named entity 'time' named entity 'temporal' named entity 'lungs' named entity 'binding' named entity 'induction' named entity 'alveolar macrophages' named entity 'deficient mice' named entity 'gene expression studies' named entity 'alveolar' named entity 'Flow cytometry' named entity 'mice' named entity 'lungs' named entity 'infection' named entity 'lung' named entity '7 days' named entity 'infection' named entity 'cDNA' named entity 'Lung tissue' named entity 'elastin' named entity 'microvascular permeability' named entity 'pathology' named entity 'forced oscillation' named entity 'Tween 20' named entity 'Csf2' named entity 'dimerization' named entity 'Institutional Animal Care and Use Committee' named entity 'paracrine' named entity 'albumin' named entity 'sucrose' named entity 'fluorochrome' named entity 'digital camera' named entity 'lung lavage' named entity 'alveoli' named entity 'arginase 1' named entity 'elastance' named entity 'CD64' named entity 'San Diego' named entity 'alveolar spaces' named entity 'infection' named entity 'Anesthetized' named entity 'infection' named entity 'Flow cytometric' named entity 'MPEF' named entity 'lung injury' named entity 'Public Health Service' named entity 'ThermoFisher' named entity 'enhancer' named entity 'infection' named entity 'protein' named entity 'inflammatory mediators' named entity 'IAV'

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