About: Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI): study protocol

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About: Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI): study protocol Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI): study protocol
Creator	Malosh, Ryan Monto, Arnold Azziz-Baumgartner, Eduardo Levine, Min Greenberg, David Katz, Mark Davidovitch, Nadav Glatman-Freedman, Aharona Thompson, Mark Hertz, Tomer Martin, Emily Campbell, William Ferdinands, Jill Avni, Yonat Gofer, Ilan Gur-Arie, Rachel Hirsch, Avital Laufer Peretz, Alon Leventer-Roberts, Maya Manuel, Joan Newes-Adeyi, Gabriella Quijandría, Neyra Rosenthal, Anat Wendlandt, Rachael
Source	Medline; PMC
abstract	BACKGROUND: The Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI) prospectively follows a cohort of healthcare personnel (HCP) in two hospitals in Israel. SHIRI will describe the frequency of influenza virus infections among HCP, identify predictors of vaccine acceptance, examine how repeated influenza vaccination may modify immunogenicity, and evaluate influenza vaccine effectiveness in preventing influenza illness and missed work. METHODS: Cohort enrollment began in October, 2016; a second year of the study and a second wave of cohort enrollment began in June 2017. The study will run for at least 3 years and will follow approximately 2000 HCP (who are both employees and members of Clalit Health Services [CHS]) with routine direct patient contact. Eligible HCP are recruited using a stratified sampling strategy. After informed consent, participants complete a brief enrollment survey with questions about occupational responsibilities and knowledge, attitudes, and practices about influenza vaccines. Blood samples are collected at enrollment and at the end of influenza season; HCP who choose to be vaccinated contribute additional blood one month after vaccination. During the influenza season, participants receive twice-weekly short message service (SMS) messages asking them if they have acute respiratory illness or febrile illness (ARFI) symptoms. Ill participants receive follow-up SMS messages to confirm illness symptoms and duration and are asked to self-collect a nasal swab. Information on socio-economic characteristics, current and past medical conditions, medical care utilization and vaccination history is extracted from the CHS database. Information about missed work due to illness is obtained by self-report and from employee records. Respiratory specimens from self-collected nasal swabs are tested for influenza A and B viruses, respiratory syncytial virus, human metapneumovirus, and coronaviruses using validated multiplex quantitative real-time reverse transcription polymerase chain reaction assays. The hemagglutination inhibition assay will be used to detect the presence of neutralizing influenza antibodies in serum. DISCUSSION: SHIRI will expand our knowledge of the burden of respiratory viral infections among HCP and the effectiveness of current and repeated annual influenza vaccination in preventing influenza illness, medical utilization, and missed workdays among HCP who are in direct contact with patients. TRIAL REGISTRATION: NCT03331991. Registered on November 6, 2017. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-018-3444-7) contains supplementary material, which is available to authorized users.
has issue date	2018-11-06(xsd:dateTime)
bibo:doi	10.1186/s12879-018-3444-7
bibo:pmid	30400834
has license	cc-by
sha1sum (hex)	5c0b4c3d3f9d2f158b8019133808fea3388cfe70
schema:url	https://doi.org/10.1186/s12879-018-3444-7
resource representing a document's title	Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI): study protocol
has PubMed Central identifier	PMC6220521
has PubMed identifier	30400834
schema:publication	BMC Infect Dis
resource representing a document's body	covid:5c0b4c3d3f9d2f158b8019133808fea3388cfe70#body_text
is schema:about of	named entity 'SERUM' named entity 'HOW' named entity 'FOLLOW' named entity 'VACCINE EFFECTIVENESS' named entity 'SMS' named entity '2000' named entity 'INFORMED CONSENT' named entity 'YEAR' named entity 'BLOOD' named entity 'CHARACTERISTICS' named entity 'EMPLOYEE' named entity 'ILL' named entity 'ECONOMIC' named entity 'CORONAVIRUSES' named entity 'MULTIPLEX' named entity 'COMPLETE' named entity 'VACCINE' named entity 'PAST' named entity 'HAVE' named entity 'HCP' named entity 'INFLUENZA VACCINE' named entity 'CURRENT' named entity 'MESSAGE' named entity 'IDENTIFY' named entity 'ASKING' named entity 'REPEATED' named entity 'RESPONSIBILITIES' named entity 'Influenza' named entity 'vaccine' named entity 'short message service' named entity 'Israel' named entity 'vaccination' named entity 'metapneumovirus' named entity 'Viruses' named entity 'influenza' named entity 'follow-up' named entity 'influenza vaccination' named entity 'immunogenicity' named entity 'assay' named entity 'Israel' named entity 'influenza vaccines' named entity 'influenza vaccine' named entity 'presenteeism' named entity 'respiratory illness' named entity 'H3N2' named entity 'follow-up' named entity 'influenza' named entity 'influenza vaccine' named entity 'viruses' named entity 'serologic' named entity 'influenza vaccination' named entity 'influenza' named entity 'influenza' named entity 'SMS' named entity 'Glasgow' named entity 'CHS' named entity 'influenza infection' named entity 'antibody'

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