About: Molecular characterization of low pathogenic avian influenza viruses, isolated from food products imported into Singapore

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About: Molecular characterization of low pathogenic avian influenza viruses, isolated from food products imported into Singapore Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular characterization of low pathogenic avian influenza viruses, isolated from food products imported into Singapore
Creator	Tan, Boon-Huan Liaw, Chin-Wen Lim, Chee-Wee Ng, Ley-Moy Ng, Sock-Hoon Wong, Wai-Kwan Sugrue, Richard Dawn, Su-Yin Lay-Kheng, Shirely Lim, Ai-Sim Seah, Wee, Jing-Hui Yeo,
Source	Elsevier; Medline; PMC
abstract	We have completed the genetic characterization of all eight gene segments for four low pathogenic avian influenza (LPAI) viruses. The objective of this study was to detect the presence of novel signatures that may serve as early warning indicators of the conversion of LPAI viruses to high pathogenic avian influenza (HPAI) viruses. This study included three H5N2 and one H5N3 viruses that were isolated from live poultry imported into Singapore as part of the national avian influenza virus (AIV) surveillance program. Based on the molecular criterion of the World Organisation for Animal Health (OIE), sequence analysis with the translated amino acid (aa) sequence of the hemagglutinin (HA) gene revealed the absence of multibasic aa at the HA cleavage site, identifying all four virus isolates as LPAI. Detailed phylogenetic tree analyses using the HA and neuraminidase (NA) genes clustered these isolates in the Eurasian H5 lineage, but away from the HPAI H5 subtypes. This analysis further revealed that the internal genes clustered to different avian and swine subtypes, suggesting that the four isolates may possibly share their ancestry with these different influenza subtypes. Our results suggest that the four LPAI isolates in this study contained mainly avian signatures, and the phylogenetic tree for the internal genes further suggests the potential for reassortment with other different circulating avian subtypes. This is the first comprehensive report on the genetic characterization of LPAI H5N2/3 viruses isolated in South-East Asia.
has issue date	2009-09-18(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2009.04.025
bibo:pmid	19464126
has license	no-cc
sha1sum (hex)	5c103d4a5653649f6940c918b784617148e66be3
schema:url	https://doi.org/10.1016/j.vetmic.2009.04.025
resource representing a document's title	Molecular characterization of low pathogenic avian influenza viruses, isolated from food products imported into Singapore
has PubMed Central identifier	PMC7125998
has PubMed identifier	19464126
schema:publication	Vet Microbiol
resource representing a document's body	covid:5c103d4a5653649f6940c918b784617148e66be3#body_text
is schema:about of	named entity 'SINGAPORE' named entity 'IMPORTED' named entity 'FOOD PRODUCTS' named entity 'CHARACTERIZATION' named entity 'AVIAN INFLUENZA' named entity 'LOW' named entity 'MOLECULAR' named entity 'ISOLATED' named entity 'PATHOGENIC' named entity 'INFLUENZA VIRUSES' named entity 'Singapore' named entity 'avian influenza viruses' named entity 'N165' named entity 'H5N2' named entity 'C-terminus' named entity 'genus' named entity 'pathogenicity' named entity 'sequence identity' named entity 'H5N3' named entity 'N302' named entity 'seasonal influenza' named entity 'poultry' named entity 'influenza' named entity 'gene' named entity 'H5N2' named entity 'post-translational cleavage' named entity 'glutamic acid' named entity 'Genbank' named entity 'Flu' named entity 'binding affinity' named entity 'Netherlands' named entity 'H5N3' named entity 'F118' named entity 'chicken' named entity 'protein' named entity 'poultry farms' named entity 'HPAI' named entity 'mortality rate' named entity 'Malaysia' named entity 'infection' named entity 'swine' named entity 'glycosylation' named entity 'infectious diseases' named entity 'HPAI' named entity 'H5N2' named entity 'OIE' named entity 'amantadine' named entity 'cleavage site' named entity 'F118' named entity 'antigens' named entity 'F118' named entity 'amantadine' named entity 'Ireland' named entity 'AIV' named entity 'H5N2' named entity 'avian influenza' named entity 'F189' named entity 'Malaysia' named entity 'chicken' named entity 'RT-PCR' named entity 'virulence' named entity 'viral replication' named entity 'cleavage site' named entity 'H9N2' named entity 'viruses' named entity 'F119' named entity 'amino acid residues' named entity 'Capua' named entity 'F118'

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