About: Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses
Creator	Li, Yue Modis, Yorgo Wang, Jimin
Source	Elsevier; Medline; PMC
abstract	Abstract The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys987 in E2 as the site of disulfide bond linkage with E1 to form E1–E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain.
has issue date	2014-04-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2014.02.015
bibo:pmid	24725935
has license	els-covid
sha1sum (hex)	5c1a091ca3849b090aea66230a34b1fb16a77faa
schema:url	https://doi.org/10.1016/j.virol.2014.02.015
resource representing a document's title	Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses
has PubMed Central identifier	PMC3986810
has PubMed identifier	24725935
schema:publication	Virology
resource representing a document's body	covid:5c1a091ca3849b090aea66230a34b1fb16a77faa#body_text
is schema:about of	named entity 'geometric' named entity 'viral envelope proteins' named entity 'heterodimers' named entity 'MEMBRANE FUSION' named entity 'POINT' named entity 'SHORT' named entity 'transmembrane helix' named entity 'site' named entity 'backbone' named entity 'pair' named entity 'cell' named entity 'membrane' named entity 'amphipathic' named entity 'heterodimers' named entity 'Structural models' named entity 'N-linked glycans' named entity 'disulfide bonds' named entity 'Secondary structure' named entity 'polyprotein' named entity 'ectodomain' named entity 'serine' named entity 'pestivirus' named entity 'hydrogen bond' named entity 'protein sequence' named entity 'paramyxoviruses' named entity 'arginine' named entity 'snorkeling' named entity 'π-stacking' named entity 'aspartate' named entity 'crystal structures' named entity 'HCV' named entity 'outer membrane' named entity 'lipid bilayers' named entity 'cell membrane' named entity 'epitope' named entity 'transmembrane' named entity 'genome' named entity 'homodimers' named entity 'electrostatic potential' named entity 'fusion pore' named entity 'pestivirus' named entity 'disulfide link' named entity 'amphipathic' named entity 'amphipathic' named entity 'binding affinity' named entity 'Jpred' named entity 'enveloped viruses' named entity 'epitope' named entity 'border disease' named entity 'Dessau' named entity 'Jpred' named entity 'endosomal' named entity 'bovine viral diarrhea virus' named entity 'cellular membrane' named entity 'baculoviruses' named entity 'heterotetrameric' named entity 'viral membrane' named entity 'coiled-coil' named entity 'disulfide linkages' named entity 'Cys' named entity 'non-covalent interactions' named entity 'BVDV' named entity 'Weybridge' named entity 'epitopes' named entity 'antigenic' named entity 'intermolecular' named entity 'ectodomain' named entity 'computational modeling' named entity 'helix bundle' named entity 'fusion proteins' named entity 'ectodomain' named entity 'hydrogen bonding' named entity 'cell membrane' named entity 'classical swine fever virus' named entity 'heterodimer' named entity 'computational model' named entity 'ectodomain' named entity 'helix' named entity 'aromatic side chains'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software