About: ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease

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About: ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease
Creator	Hosking, Martin Lane, Thomas Pluchino, Stefano
Source	PMC
abstract	Intracranial infection of the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis, accompanied by viral replication in glial cells and robust infiltration of virus-specific T cells that contribute to host defense through cytokine secretion and cytolytic activity. Mice surviving the acute stage of disease develop an immune-mediated demyelinating disease, characterized by viral persistence in white matter tracts and a chronic neuroinflammatory response dominated by T cells and macrophages. Chemokines and their corresponding chemokine receptors are dynamically expressed throughout viral infection of the CNS, influencing neuroinflammation by regulating immune cell infltration and glial biology. This review is focused upon the pleiotropic chemokine receptor CXCR2 and its effects upon neutrophils and oligodendrocytes during JHMV infection and a number of other models of CNS inflammation.
has issue date	2014-06-17(xsd:dateTime)
bibo:doi	10.3389/fncel.2014.00165
bibo:pmid	24987333
has license	cc-by
sha1sum (hex)	5c4e986c0995292d3e3839bb20c20b95039ae9d4
schema:url	https://doi.org/10.3389/fncel.2014.00165
resource representing a document's title	ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease
has PubMed Central identifier	PMC4060560
has PubMed identifier	24987333
schema:publication	Front Cell Neurosci
resource representing a document's body	covid:5c4e986c0995292d3e3839bb20c20b95039ae9d4#body_text
is schema:about of	named entity 'ELR' named entity 'disease' named entity 'accompanied' named entity 'chronic' named entity 'signaling' named entity 'disease' named entity 'ARTICLE' named entity 'MODEL OF' named entity 'REVIEW' named entity 'VIRAL' named entity 'MINI' named entity 'MOUSE HEPATITIS VIRUS' named entity 'VIRAL REPLICATION' named entity 'VIRAL PERSISTENCE' named entity 'BIOLOGY' named entity 'ROBUST' named entity 'EFFECTS' named entity 'CYTOKINE SECRETION' named entity 'CHEMOKINE RECEPTORS' named entity 'ENCEPHALOMYELITIS' named entity 'NUMBER OF' named entity 'CHARACTERIZED' named entity 'VIRAL INFECTION' named entity 'FOCUSED' named entity 'ACUTE' named entity 'CNS INFLAMMATION' named entity 'REVIEW' named entity 'T CELLS' named entity 'DEMYELINATING DISEASE' named entity 'GLIAL' named entity 'SPECIFIC' named entity 'NEUTROPHILS' named entity 'MODELS' named entity 'NEUROINFLAMMATORY RESPONSE' named entity 'CXCR2' named entity 'GLIAL CELLS' named entity 'OLIGODENDROCYTES' named entity 'CHEMOKINES' named entity 'DISEASE' named entity 'INTRACRANIAL INFECTION' named entity 'CONTRIBUTE ' named entity 'CHEMOKINE RECEPTOR' named entity 'STRAINS' named entity 'CNS' named entity 'MACROPHAGES' named entity 'HOST DEFENSE' named entity 'VIRUS' named entity 'EXPRESSED' named entity 'REGULATING' named entity 'ARTICLE' named entity 'CHEMOKINE' named entity 'SIGNALING' named entity 'CENTRAL NERVOUS SYSTEM DISEASE' named entity 'RESULTS' named entity 'WHITE MATTER' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'IMMUNE-MEDIATED' named entity 'STRAIN' named entity 'HOST DEFENSE' named entity 'ACUTE STAGE' named entity 'NEUROINFLAMMATION' named entity 'TRACTS' named entity 'CHRONIC' named entity 'CELLULAR NEUROSCIENCE' named entity 'ITS' named entity 'MICE' named entity 'THEIR' named entity 'IMMUNE CELL' named entity 'NEUROTROPIC' named entity 'INFECTION' named entity 'ACTIVITY' named entity 'INFILTRATION' named entity 'SUSCEPTIBLE' named entity 'STAGE OF DISEASE' named entity 'chemokine receptor' named entity 'T cells' named entity 'effects' named entity 'Chemokines' named entity 'infection'

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