About: A functional subset of CD8(+) T cells during chronic exhaustion is defined by SIRPα expression

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About: A functional subset of CD8(+) T cells during chronic exhaustion is defined by SIRPα expression Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A functional subset of CD8(+) T cells during chronic exhaustion is defined by SIRPα expression
Creator	Carmody, Aaron Markovic, Maxim Hasenkrug, Kim Messer, Ronald Weissman, Irving Davis, Mark Sinha, Rahul Ahmed, Aijaz Pham, Edward Bear Torrez Dulgeroff, Laughing Caspi Tal, Michal Fram, Benjamin Glenn, Jeffrey Gulati, Gunsagar Kaech, Susan Lopez Angel, Cesar Myers, Lara Newman, Aaron Staron, Matthew Yiu, Ying
Source	Medline; PMC
abstract	Prolonged exposure of CD8(+) T cells to antigenic stimulation, as in chronic viral infections, leads to a state of diminished function termed exhaustion. We now demonstrate that even during exhaustion there is a subset of functional CD8(+) T cells defined by surface expression of SIRPα, a protein not previously reported on lymphocytes. On SIRPα(+) CD8(+) T cells, expression of co-inhibitory receptors is counterbalanced by expression of co-stimulatory receptors and it is only SIRPα(+) cells that actively proliferate, transcribe IFNγ and show cytolytic activity. Furthermore, target cells that express the ligand for SIRPα, CD47, are more susceptible to CD8(+) T cell-killing in vivo. SIRPα(+) CD8(+) T cells are evident in mice infected with Friend retrovirus, LCMV Clone 13, and in patients with chronic HCV infections. Furthermore, therapeutic blockade of PD-L1 to reinvigorate CD8(+) T cells during chronic infection expands the cytotoxic subset of SIRPα(+) CD8(+) T cells.
has issue date	2019-02-15(xsd:dateTime)
bibo:doi	10.1038/s41467-019-08637-9
bibo:pmid	30770827
has license	cc-by
sha1sum (hex)	5c5778727b4b3b32b11693ce4082adf30417a67b
schema:url	https://doi.org/10.1038/s41467-019-08637-9
resource representing a document's title	A functional subset of CD8(+) T cells during chronic exhaustion is defined by SIRPα expression
has PubMed Central identifier	PMC6377614
has PubMed identifier	30770827
schema:publication	Nat Commun
resource representing a document's body	covid:5c5778727b4b3b32b11693ce4082adf30417a67b#body_text
is schema:about of	named entity 'PD-L1' named entity 'chronic' named entity 'subset' named entity 'therapeutic' named entity 'mice' named entity 'receptors' named entity 'LCMV' named entity 'susceptible' named entity 'SIRPα' named entity 'defined' named entity 'cytolytic' named entity 'counterbalanced' named entity 'gene' named entity 'SIRPα' named entity 'viruses' named entity 'homeostasis' named entity 'viruses' named entity 'peptides' named entity 'upregulation' named entity 'CD8 +' named entity 'SIRPα' named entity 'Gene expression' named entity 'SIRPα' named entity 'genotype' named entity 'STAT3' named entity 'SIRPα' named entity 'cytotoxic' named entity 'CD8' named entity 'vivo' named entity 'proliferate' named entity 'activity' named entity 'SIRPα' named entity 'T cells' named entity 'HCV' named entity 'cytolytic activity' named entity 'Clone' named entity 'antigenic' named entity 'co-stimulatory receptors' named entity 'diminished function' named entity 'cytotoxic' named entity 'SIRPα' named entity 'IFNγ' named entity 'target cells' named entity 'CD8 +' named entity 'SIRPα' named entity 'SIRPα' named entity 'cell surface markers' named entity 'SIRPα' named entity 'statistically significant' named entity 'intravenously' named entity 'SIRPα' named entity 'mice' named entity 'transcription factor' named entity 'CD47' named entity 'CD3' named entity 'CD3' named entity 'CD8' named entity 'SIRPα' named entity 'CD8 +' named entity 'SIRPα' named entity 'CD8 +' named entity 'hematopoietic'

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